Effect of Nitrate Supplementation on Blood Pressure and Microvascular Function of Resistant Hypertensive Patients
Arterial hypertension (AH) has been identified as an important public health problem and considered a new epidemic with high mortality and morbidity. High blood pressure (BP) levels increase the chances of coronary artery disease (CAD), heart failure (HF), stroke, chronic renal failure (CRF) and death. Beetroot powder may be an easier way to increase the availability of nitric oxide and consequently vasodilation in these patients. However, studies are needed to evaluate its benefits in patients with AH.
Conditions studied
Arterial Hypertension, Resistant Hypertension, Microvascular Function, Nitrate Supplementation
About this study
Arterial hypertension (AH) has been identified as an important public health problem and considered a new epidemic with high mortality and morbidity. High blood pressure (BP) levels increase the chances of coronary artery disease (CAD), heart failure (HF), stroke, chronic renal failure (CRF) and death. Beetroot powder may be an easier way to increase the availability of nitric oxide and consequently vasodilation in these patients. However, studies are needed to evaluate its benefits in patients with AH.
Interventions
- Dietary Supplement: Beetroot extract — Beetroot extract powder supplementation with 400mg of nitrate per dose in the amount of 10g per day orally will be used in the group.
- Dietary Supplement: Placebo — The placebo will be administered as a colored and flavored isocaloric supplement composed of maltodextrin.
Primary outcomes
- Assessment of blood pressure evolution (60 days)
Eligibility information
Study locations
- National Institute of Cardiology, Rio de Janeiro, 21040-360 Brazil
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-10-23.