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Frailty, Physical Capacity and Lung Function in Postoperative Pulmonary Endarterectomy Patients
The goal of this observational and prospective study is to investigate changes in physical performance, lung function, respiratory and peripheral muscle strength in patients during the postoperative period following pulmonary endarterectomy (PET).
ClinicalTrials.gov IDNCT06286891
PhaseNot Applicable
Enrollment50
SponsorUniversity of Sao Paulo General Hospital
Age18 Years
SexALL
Conditions studied
Chronic Thromboembolic Pulmonary Hypertension, Physical Disability, Fragility
About this study
The goal of this observational and prospective study is to investigate changes in physical performance, lung function, respiratory and peripheral muscle strength in patients during the postoperative period following pulmonary endarterectomy (PET).
Primary outcomes
- To investigate changes in physical performance measured by Six-Minute Walk Test. (Baseline (one day before the surgery), after the surgery (the day immediately ICU discharge), before the hospital discharge (an average of 20 days) and 6 months after the surgery.)
- To investigate changes in physical performance measured by Short Physical Performance Battery (SPPB). (Baseline (one day before the surgery), after the surgery (the day immediately after ICU discharge), before the hospital discharge (an average of 20 days) and 6 months after surgery.)
- To investigate changes in physical performance by 1-minute sit-to-stand test (1-MSTST). (Baseline (one day before the surgery), after the surgery (the day immediately ICU discharge), before the hospital discharge (an average of 20 days) and 6 months after the surgery)
- To investigate changes in peripheral muscle strength. (Baseline (one day before the surgery), after the surgery (the day immediately ICU discharge), before the hospital discharge (an average of 20 days) and 6 months after the surgery)
- To investigate changes in respiratory muscle strength: (Baseline (one day before the surgery), after the surgery (the day immediately ICU discharge), before the hospital discharge (an average of 20 days) and 6 months after the surgery)
- To investigate changes in lung function test measure by spirometry: (Baseline (one day before the surgery), after the surgery (the day immediately ICU discharge), before the hospital discharge (an average of 20 days) and 6 months after the surgery)
- To investigate frailty by Clinical Frailty Scale (CFS) (Baseline (one day before the surgery), after the surgery (the day immediately ICU discharge), before the hospital discharge (an average of 20 days) and 6 months after the surgery)
Eligibility information
Inclusion Criteria:
* Age ≥ 18 years
* Both genders
* Elective pulmonary endarterectomy surgery
* Absence of cognitive or peripheral motor impairment that prevents the performance of functional tests in the preoperative period.
Exclusion Criteria:
* Reoperation for any reason
* Presence of cognitive or peripheral motor impairment that prevents the performance of functional tests in the postoperative period.
Study locations
- Instituto do Coração - Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo 05403-000 Brazil
Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.