Recruiting
Effect of CPAP Treatment in Patients With Severe Uncontrolled Asthma: The ASTHMA-SLEEP Trial
The aim of the study is to evaluate the impact of CPAP treatment on asthma control in patients with severe uncontrolled asthma and obstructive sleep apnea (OSA)
ClinicalTrials.gov IDNCT06314477
PhaseNA
Enrollment138
SponsorHospital Clinic of Barcelona
Age18 Years
SexALL
Conditions studied
Obstructive Sleep Apnea, Asthma
About this study
The aim of the study is to evaluate the impact of CPAP treatment on asthma control in patients with severe uncontrolled asthma and obstructive sleep apnea (OSA)
Interventions
- Device: CPAP treatment — Subjects allocated to this arm will receive continuous positive airway pressure (CPAP)
- Other: Hygienic and dietary advice — Subjects allocated to this arm will receive hygienic and dietary counselling
Primary outcomes
- Asthma control questionnaire (12 months)
- Asthma control test (12 months)
Eligibility information
Inclusion Criteria:
* Age \>18 years
* Diagnosis of severe uncontrolled asthma according to the criteria of the Spanish Asthma Management Guide (GEMA) or the Global Initiative for Asthma (GINA) and no hospitalizations the month prior to inclusion in the study.
* Apnea hypopnea rate greater than or equal to 15/hour
* Punctuation in the Epworth Sleepiness Scale ≤10
* Obtaining informed consent.
Exclusion Criteria:
* Previous treatment with CPAP
* Patient with central sleep apnea or Cheyne-Stokes respiration
* Other sleep disorders: narcolepsy, restless leg syndrome, chronic insomnia,
* Resistant hypertension
* Active Smoking
* Unstable comorbidities or medications may interfere with asthma control
* Pregnancy
* Any process that reduces life expectancy to \<1 year,
* Any medical or social factor that may limit CPAP compliance
Study locations
- Hospital Clinic Barcelona, Barcelona, Spain 08036 Spain
Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.