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Physical Activity to Mitigate PreEclampsia Risk

The purpose of this study is to compare the effects of aerobic (AE), resistance (RE), and combination (AERE) exercise throughout pregnancy on selected maternal and fetal/neonatal physiological variables in women at-risk for preeclampsia. The central hypothesis of this project is that exercise will decrease severity and occurrence of preeclampsia symptoms, thus improving maternal, pregnancy, and birth outcomes. Aim 1. Determine the influence of different exercise modes during pregnancy at risk of preeclampsia on…

ClinicalTrials.gov IDNCT06319014

PhaseNA

Enrollment224

SponsorEast Carolina University

Age18 Years

SexFEMALE

I'm interested View official listing

Conditions studied

Pre-Eclampsia

About this study

Interventions

Behavioral: Exercise Modes — Moderate intensity aerobic exercise Moderate intensity resistance exercise Moderate intensity combination exercise

Primary outcomes

Systolic Blood Pressure (16wks) (16 weeks gestation)
Systolic Blood Pressure (20wks) (20 weeks gestation)
Systolic Blood Pressure (24wks) (24 weeks gestation)
Systolic Blood Pressure (28wks) (28 weeks gestation)
Systolic Blood Pressure (32wks) (32 weeks gestation)
Systolic Blood Pressure (36wks) (36 weeks gestation)
Maternal Cardiometabolic Risk (CMR) Score (during pregnancy)
Symptom Occurrence (at delivery)

Eligibility information

Inclusion Criteria: * healthy women, age 18-40 years, \<16 weeks' gestation, with singleton pregnancy; women (BMI:18.5-45.0), sedentary, cleared by their obstetric provider. Exclusion Criteria: * pre-existing chronic conditions such as HIV, lupus, etc.; taking medicines that affect fetal development; and/or lack of telephone or email contact information).

Study locations

East Carolina University, Greenville, North Carolina 27834 United States

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.