Recruiting

The Acute T-Rex (Timing of Resistance Exercise) Study

ClinicalTrials.gov IDNCT06366399

PhaseNA

Enrollment20

SponsorUniversity of Utah

Age50 Years

SexALL

I'm interested View official listing

Conditions studied

Diabetes Mellitus, Type 2, Insulin Resistance, Glucose Intolerance, Sleep Disturbance, Overweight or Obesity, Insulin Sensitivity

About this study

The primary aim of this study is to evaluate if a single bout of AM vs PM resistance exercise has different effects on insulin sensitivity and sleep. A randomized cross-over trial be used to compare resistance exercise at two different times of the day. Each condition will take place in a laboratory setting. Each condition will consist of exercise, overnight sleep, and oral glucose tolerance tests the following day. The AM exercise will occur \~1.5 hours after habitual wake, and PM exercise will occur \~11 hours after habitual wake. After a 2-6 week washout, participants will complete the other condition. The hypothesis is that PM exercise will be more beneficial than AM exercise in improving insulin sensitivity. This study could identify if there is a better time of day to perform resistance exercise to decrease risk of developing Type 2 Diabetes Mellitus.

Interventions

Behavioral: Resistance Exercise Timing — 1 resistance exercise session consisting of 3 sets, 10 repetitions per set, on 12 different exercises

Primary outcomes

Insulin sensitivity (1 day)

Eligibility information

Inclusion Criteria: * Men and women, all ethnicities, aged 50-74 years * BMI ≥25 kg/m² and \<45 kg/m² * Weight stable (less than 5% change in the past 6 months) * Generally healthy individuals * Not meeting recommended activity guidelines for aerobic or resistance exercise Exclusion Criteria: * Uncontrolled cardiovascular, metabolic, renal, or pulmonary disease * Cancer treatment in the past 5 years * Untreated thyroid disease or other medical conditions affecting weight or energy metabolism * Current use of weight loss medication or other medications likely to impact energy balance * Bariatric surgery or extensive bowel resection in the past 2 years * Current or recent history (past 2 years) of eating disorder * Diagnosis of insomnia, sleep apnea, or other sleep and circadian disorders * Non-English speaking * HbA1c \>6.5%

Study locations

University of Utah HPER E Buildling, Salt Lake City, Utah 84112 United States

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.