Pulmonary Hypertension and Oxygen Saturation Targeting in Preterm Infants

Conditions studied

Bronchopulmonary Dysplasia, Pulmonary Hypertension

About this study

Around 50% of infants born extremely preterm develop a chronic lung disease known as bronchopulmonary dysplasia of which some infants will also develop pulmonary hypertension of which 50% of children will die before the age of 2. Physicians are currently limited in their ability to select the most appropriate oxygen targets that will improve outcomes in infants with this condition. This clinical trial will determine whether using different amounts of oxygen improve outcomes in infants with this disease.

Interventions

• Device: higher oxygen saturation target using Nellcor pulse oximetry sensors — The intervention will be a cross over exposure to the higher oxygen saturation target.
• Device: lower oxygen saturation target using Nellcor pulse oximetry sensors — The intervention will be a cross over exposure to the lower oxygen saturation target.

Primary outcomes

• Intermittent hypoxemia event duration (From date of randomization until 3 weeks have elapsed or date of discharge, whichever came first)

Eligibility information

Study locations

• The University of Alabama at Birmingham, Birmingham, Alabama 35294 United States
• Yale New Haven Hospital, New Haven, Connecticut 06510 United States