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A Novel Individualized Connectome-guided Approach for Precision Intermittent Theta Burst Stimulation for Depression

The Investigators propose to carry out a randomized, double-blind trial to compare the clinical efficacy of an individualized connectome-guided accelerated iTBS vs an anatomically-guided (Beam F3) accelerated iTBS. The study team will recruit both inpatients and outpatients who had been referred for TMS for the treatment of depression.

ClinicalTrials.gov IDNCT06385223

PhaseNA

Enrollment70

SponsorInstitute of Mental Health, Singapore

Age21 Years and older

SexALL

I'm interested View official listing

Conditions studied

Depression

About this study

Interventions

Device: Beam F3 targeted accelerated iTBS — Magpro X100, Axilium Cobot, Localite camera
Device: Individualized connectome-guided accelerated iTBS — Magpro X100, Axilium Cobot, Localite camera

Primary outcomes

Montgomery-Åsberg Depression Rating Scale (Baseline, immediately post treatment, 1 month and 3 months post intervention)

Eligibility information

Inclusion Criteria: 1. Age ≥ 21 years. 2. DSM-5 diagnosis of current Major Depressive Episode. 3. Montgomery-Asberg Depression Rating Scale score of 20 or more. 4. Inadequate response to an adequate trial (4 weeks) of at least one antidepressant medication. 5. Able to give informed consent. Exclusion Criteria: 1. DSM-5 psychotic disorder 2. Drug or alcohol abuse or dependence (preceding 3 months). 3. Rapid clinical response required, e.g., high suicide risk. 4. Significant neurological disorder, which may pose increased risks with TMS, e.g., epilepsy. 5. Metal in the cranium, skull defects, pacemaker, cochlear implant, medication pump or other electronic device. 6. Pregnancy. 7. Unsuitable for MRI.

Study locations

Institute of Mental Health, Singapore, 539747 Singapore

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-10-26.