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Developing the Probability Algorithm for Pulmonary Hypertension Echocardiography

The goal of this observational study is to assess the efficacy that the addition of novel markers cardiac function, particularly of right ventricular (RV) function in echocardiography, and ECG have in detecting pulmonary hypertension. The main questions it aims to answer are: Can novel markers in ECG and echocardiography suggest the presence of PH? Can existing screening guidelines be improved with the addition of these markers?

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ClinicalTrials.gov IDNCT06386185

PhaseNot Applicable

Enrollment2500

SponsorRoyal United Hospitals Bath NHS Foundation Trust

Age18 Years and older

SexALL

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Conditions studied

Pulmonary Hypertension

About this study

Interventions

Diagnostic Test: Electrocardiogram — Non-invasive multi-vector voltage/time graph visualising the electrical conduction of the heart
Diagnostic Test: Transthoracic echocardiogram — Non-invasive 2 \& 3 dimensional imaging of the heart using ultrasound
Diagnostic Test: Right heart catheter — Minimally invasive cardiac chamber pressure measurement using balloon catheterisation

Primary outcomes

Distinguish between patients with and without pulmonary hypertension (2 years)
Distinguish between patients with pre-capillary hypertension and post-capillary hypertension (2 years)

Eligibility information

Inclusion Criteria: * Patients 18+ who have undergone TTE, ECG and RHC as part of their clinical care Exclusion Criteria: * Patients \<18 years old * Known or suspected congenital heart disease * Patient has opted-out of allowing their data to be used for research and planning (via the national data opt-out choice in England, or equivalent data protection scheme in Scotland)

Study locations

Royal United Hospital NHS Foundation Trust, Bath, Banes BA1 3NG United Kingdom
Golden Jubilee Hospital, Glasgow, Lanarkshire G81 4DY United Kingdom
Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, South Yorkshire S10 2JF United Kingdom
Royal Papworth Hospital, Cambridge, CB2 0AY United Kingdom
Royal Free NHS Foundation Trust, London, NW3 2QG United Kingdom

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-11-15.