Recruiting

An Innovative Master Platform for Clinical Trials in Mood Disorders

ClinicalTrials.gov IDNCT06408012

PhaseNot Applicable

Enrollment2200

SponsorSt. Joseph's Healthcare Hamilton

Age16 Years

SexALL

I'm interested View official listing

Conditions studied

Mood Disorders, Depressive Disorder, Bipolar and Related Disorders

About this study

Mood disorders such as depression and bipolar disorder affect over 350 million people around the world. While several effective treatments exist, it is often difficult to match the right treatment to an individual person. Repeated efforts to find the right treatment contribute to poor functioning, low quality of life, and prolongs the time it takes to get well. Most areas of medicine are able to use 'biomarkers' or clinical tests, blood tests, or imaging to help diagnose and treat illness. The search for biomarkers in mood disorders is advancing, but one roadblock to progress is the lack of large, standardized studies of mood disorders that are needed to accurately identify biomarkers. The aim of the ENABLE platform is to provide the Canadian neuroscience community a standardized way of collecting biomarker data from individuals with a range of mood disorders symptoms. In addition, this 'master clinical trial platform' framework will provide a pool of participants who can be recruited into biomarker-based clinical trials.

Primary outcomes

Rate of participation in the master trial platform (31st March 2026)

Eligibility information

Inclusion Criteria Patients: 1. 16 years of age or older. 2. Meet criteria for bipolar or depressive disorders as defined by DSM-5. 3. Fluency in English, sufficient to complete the interviews and self-report questionnaires. Inclusion Criteria Healthy Comparison (HC) Participants: 1. 16 years of age or older. 2. No history of psychiatric disorders (according to DSM-5) or significant unstable medical conditions. 3. Fluency in English, sufficient to complete the interviews and self-report questionnaires.

Study locations

University of Calgary, Calgary, Alberta T2N 4Z6 Canada
University of British Columbia, Vancouver, British Columbia V6T 2A1 Canada
Nova Scotia Health Authority, Halifax, Nova Scotia B3H 2E2 Canada
McMaster University, Hamilton, Ontario L8P 3B6 Canada
Queen's University, Kingston, Ontario K7L4X3 Canada
University of Ottawa, Ottawa, Ontario K1Z 7K4 Canada
University Health Network, Toronto, Ontario M5T 2S8 Canada
Centre for Addiction and Mental Health, Toronto, Ontario M6J 1H4 Canada
Ontario Shores Centre for Mental Health Sciences, Whitby, Ontario L1N 5S9 Canada

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.