Recruiting
7T Amygdala and Citalopram Study
The goal of this study is to investigate how a common antidepressant citalopram (which increases the levels of the chemical messenger serotonin), affects how a key area of the brain involved in depression (the amygdala) responds to emotional information.
Healthy participants will undergo medical and psychiatric health screening, after which they will be assigned to receive either a single dose of citalopram (20mg) or placebo, and undergo brain scanning (7T fMRI) whilst viewing emotional faces. Since the scan uses…
ClinicalTrials.gov IDNCT06412315
PhaseNA
Enrollment50
SponsorUniversity of Oxford
Age18 Years
SexALL
Conditions studied
Emotional Processing, Cognition, Mood Disorders, Depressive Disorder, Depression
About this study
The goal of this study is to investigate how a common antidepressant citalopram (which increases the levels of the chemical messenger serotonin), affects how a key area of the brain involved in depression (the amygdala) responds to emotional information.
Healthy participants will undergo medical and psychiatric health screening, after which they will be assigned to receive either a single dose of citalopram (20mg) or placebo, and undergo brain scanning (7T fMRI) whilst viewing emotional faces. Since the scan uses high field strength, the investigators will be able to see effects of citalopram on different subfields within the amygdala which will help to understand how citalopram might be working.
Interventions
- Drug: Citalopram — Participants will receive a single dose (20mg) citalopram. Tablets encapsulated to aid blinding. To take per oral once.
- Drug: Placebo — Participants will receive a single dose of placebo (sucrose). Tablets encapsulated to aid blinding. To take per oral once
Primary outcomes
- Neural measures: fMRI BOLD univariate analysis (3 hours after dosing for approximately 1 hour)
- Neural measures: fMRI BOLD multivariate analysis (3 hours after dosing for approximately 1 hour)
Eligibility information
Inclusion Criteria:
* Participant is willing and able to give informed consent for participation in the research
* Sufficiently fluent English to understand and complete the task
Exclusion Criteria:
* Participants with ferromagnetic objects in their bodies (e.g. metal implants, vessel clips, shrapnel injuries) or with implanted devices which may be damaged by the magnet (e.g. heart pacemakers)
* Any other MRI contraindication following MRI safety screening
* History or current significant psychiatric illness (like major depressive disorder)
* Current or past diagnosis of any significant personality disorder (e.g. borderline personality disorder) according to self-report
* Diagnosis of attention deficit hyperactive disorder or autistic spectrum disorder that impairs daily functioning, requires pharmacotherapy or in the opinion of the study medic would affect the scientific integrity of the study
* Currently or within last 3 months taking psychoactive medications (requires further discussion with researcher)
* Current or within the last 3 months use of medication that might interact with the effects of citalopram or affect the scientific integrity of the study
* Known contraindication to citalopram including: past allergic reaction to citalopram or any other medicines, diagnosis of a cardiovascular condition, glaucoma, type 1 or type 2 diabetes, diagnosis of epilepsy, previous diagnosis of angle-closure glaucoma, or current use of any other medication whose use interacts with citalopram (according to British National Formulary (BNF) guidance) e.g. associated with prolonged QT-interval
* Any other current or past medical conditions which in the opinion of the study medic may interfere with the safety of the participant or the scientific integrity of the study including epilepsy/seizures, brain injury, hepatic or renal disease, diabetes, severe gastro-intestinal problems, Central Nervous System (CNS) tumours, neurological conditions
* Clinically significant abnormal values for urine drug screen, pulse, and blood pressure measurement (in accordance with Best Practice Guidance 13: 'Non-invasive measurement of blood pressure'). A participant with a clinical abnormality or parameters outside the reference range for the population being studied may be included only if the Investigator considers that the finding is unlikely to introduce additional risk factors and will not interfere with the study procedures
* Current alcohol or substance misuse disorder
* Body Mass Index under 18 and over 30
* Pregnant or planning a pregnancy, or breast feeding
* Previously taken part in a study that used similar computer tasks (MRI faces task, emotional test battery) as those in the present study
* Participation in a study that involves the use of a psychoactive medication or brain stimulation within the last three months
* Use of recreational drugs (e.g. cannabis, cocaine, amphetamines) within last three months
* Smoking \> 5 cigarettes per day, or vape a comparable amount (\> 0.5ml / a quarter of a 2ml vape);
* Typically drinks \> 6 caffeinated drinks per day (e.g. tea, coffee, coca cola, Red Bull)
* Participant is unlikely to comply with the clinical study protocol or is unsuitable for any other reason, in the opinion of the Investigator
Study locations
- University of Oxford, Department of Psychiatry, Oxford, Oxfordshire OX37JX United Kingdom
Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.