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Low Voltage Electrical Stimulation for Depression in Parkinson's Patients

The goal of this clinical trial is to determine the relative efficacy of fMRI model guided Transcranial Direct Current Stimulation (mgTDCS) in improving the depressive symptoms of patients with Parkinson's Disease (PD). The main questions it aims to answer are: 1) Can the use of mgTDCS significantly improve the self-reported level of depression and apathy in patients with PD from pre-intervention to post-intervention compared to a sham control? 2) Can the use of mgTDCS significantly normalize the cortical eeg…

ClinicalTrials.gov IDNCT06467695

PhaseNA

Enrollment40

SponsorUniversity of South Alabama

Age19 Years

SexALL

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Conditions studied

Parkinson Disease, Depressive Symptoms

About this study

Interventions

Device: BIOPAC Stimsola — Transcranial Electrical Stimulator
Device: BIOPAC Stimsola Sham (zero amps) — Transcranial Electrical Stimulator set to 0 amps

Primary outcomes

Beck Depression Inventory (BDI) Pre-post change score (One at Day 1 and one after 15 sessions of training, typically 4 weeks after study start.)
Alpha band power pre-post change score (One at Day 1 and one after 15 sessions of training, typically 4 weeks after study start.)
RBANS Working Memory (One at Day 1 and one after 15 sessions of training, typically 4 weeks after study start.)

Eligibility information

Inclusion Criteria: * 19 to 65 years in age. * Parkinson's Group must have a physician dx of Parkinson's Disease * Must meet exhibit elevated levels of depression on the Beck Depression Inventory (scores of 20 or above). * Must be willing and able to travel of the Psychology Department for EEG and tDCS sessions. * Participants who have undergone surgery for Deep Brain Stimulation implantation may be enrolled if advised to and monitored by their physician. * Read and understand spoken English. Exclusion Criteria: * No history of or being treated for epilepsy or other seizure disorders. * No history of penetrating head wounds or TBI greater than mild TBI. * No history of atypical Parkinson's

Study locations

University of South Alabama, Mobile, Alabama 36688 United States

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.