Recruiting

Biometric Changes After Intervention of Anterior Chamber Angle : an Observational Study

ClinicalTrials.gov IDNCT06492538

PhaseNot Applicable

Enrollment300

SponsorZhongshan Ophthalmic Center, Sun Yat-sen University

Age30 Years

SexALL

I'm interested View official listing

Conditions studied

Angle-closure Glaucoma, Minimally Invasive Glaucoma Surgery, Goniosynechialysis, Goniotomy, Glaucoma

About this study

The drainage angle in the anterior chamber of the eye mediates the outflow of aqueous humor, and pathological changes here can lead to high intraocular pressure and glaucoma. Minimally invasive glaucoma surgery, particularly angle surgery, has advanced recently, allowing clear visualization of angle structures like the trabecular meshwork and Schlemm's canal using surgical goniolens. Techniques for angle intervention include widening the angle, reopening closed angles, and rebuilding outflow pathways using methods such as laser peripheral iridotomy, Argon laser peripheral iridoplasty, and mechanical separation of adhered tissues. Our research team plans to conduct imaging studies to track the healing of angle tissues post-surgery, aiming to support innovation and standardization of minimally invasive angle surgery.

Interventions

Procedure: various types of angle interventions — procedures include laser peripheral iridotomy (LPI) to relieve pupillary tissue and deepen peripheral anterior chamber depth, Argon laser peripheral iridoplasty (ALPIp) to stimulate iris contraction and widen the angle, and mechanical separation of adhered angle tissues using instruments like goniosynechialysis hooks or iris repositor. Ab interno goniotomy using instruments like retina hooks, trabeculectomy hooks, or cannulas are used to incise trabecular meshwork and Schlemm's canal walls to enhance aqueous humor outflow.

Primary outcomes

Changes in biological parameters of the anterior chamber angle (12 months)

Eligibility information

Inclusion Criteria: * Glaucoma patients eligible for standalone or combined angle intervention surgeries, such as LPI, LPIP, goniosynechialysis, trabeculotomy alone or combined with surgical iridectomy or phacoemulsification and intraocular lens implantation; * Patients capable of undergoing preoperative examinations including CASIA2-OCT (anterior segment OCT), UBM, slit-lamp gonioscopy, IOL Master (or other optical biometry); * Patients willing to participate in this study, signing informed consent, and agreeing to follow-up according to the study protocol. Exclusion Criteria: * Patients with severe ocular conditions such as corneal infection, ulcer, trauma, ocular tumors, retinal vascular occlusion, and retinal detachment; * Those with various types of eye diseases that affect ocular parameter acquisition or interfere with visual field examination; * Long-term local or systemic use of glucocorticoids; * Patients with severe systemic diseases; * Pregnant or lactating women; * Unable to complete 12-month postoperative follow-up.

Study locations

Zhongshan ophthalmic center, Guangzhou, Guangdong 51006dddddd0 China

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.