Recruiting

Sleep and Light Intervention (SALI) for Menopausal Mood Dysfunction

\*\*Participants must live in San Diego County\*\* The purpose of this study is to learn more about an experimental Sleep \& Light Intervention (SALI) for menopausal mood changes or depression. Researchers want to find out whether adjusting the body's internal clock-which helps regulate sleep, hormones, mood, and energy- can improve symptoms such as depression, poor sleep, and low energy during menopause.

ClinicalTrials.gov IDNCT06678880

PhaseNA

Enrollment120

SponsorUniversity of California, San Diego

Age45 Years – 75 Years

SexFEMALE

I'm interested View official listing

Conditions studied

Depression, Depression During the Menopausal Transition, Menopausal Depression

About this study

Interventions

Behavioral: Phase Advanced Intervention (PAI) — Phase-advanced restricted sleep (i.e., sleep 9pm-1am only) for 1 night, followed by morning bright white light for 30 min/day for 2 weeks.
Behavioral: Phase Delay Intervention (PDI) — Phase-delayed restricted sleep (i.e., sleep 3am to 7am only) for 1 night, followed by evening bright white light for 30 min/day for 2 weeks.

Primary outcomes

Urinary 6-sulfatoxymelatonin (6-SMT) (Urine is collected at baseline and after completing two-week intervention.)
Structured Interview Guide for the Hamilton Rating Depression Scale with Atypical Depression Supplement (SIGH-ADS) (Completed at baseline and after completing two-week intervention.)
Patient Health Questionnaire (PHQ-9) (Completed at baseline and after completing two-week intervention.)
Sleep Quality Rating (SQR) (Completed at baseline and after completing two-week intervention.)

Eligibility information

Inclusion Criteria: * Women aged 45-75 years old * Experiencing significant down, sad or hopeless feelings that are affecting their daily life * These mood changes started or got worse during the menopause transition * Irregular or no menstrual cycle for at least 6 months * Non-smoking * Located in San Diego County Exclusion Criteria: * Untreated sleep apnea * Migraine headaches that are triggered or worsened by bright light * Currently suicidal or psychotic * History of bipolar disorder * A medical condition or job where fatigue or changes in sleep schedule could be unsafe * Planning to start, stop, or change medications in the next 4 months

Study locations

University of California San Diego Hillcrest Medical Center, San Diego, California 92103 United States

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-10-19.