Recruiting
Neurobehavioral Therapy For Epilepsy And Major Depressive Disorder
The purpose of this study is to examine the feasibility and acceptability of an online group Neuro-behavioral Therapy (NBT) with text messaging intervention for Veterans with epilepsy and major depressive disorder (MDD).
ClinicalTrials.gov IDNCT06695767
PhaseNA
Enrollment16
SponsorThe University of Texas Health Science Center, Houston
Age18 Years
SexALL
Conditions studied
Major Depressive Disorder, Epilepsy
About this study
The purpose of this study is to examine the feasibility and acceptability of an online group Neuro-behavioral Therapy (NBT) with text messaging intervention for Veterans with epilepsy and major depressive disorder (MDD).
Interventions
- Behavioral: Neurobehavioral therapy — Participants will receive an introduction session and 12 1-hour long online sessions once per week for a total of 12 weeks that are guided by the investigator who is trained in NBT.Participants will engage in tools to aid in assuming control over their seizures; contextualize their environment; identify moods, situations, and thoughts; train healthy communication and support seeking; understand central nervous system medications and seizures; conduct a functional behavioral analysis; learn relaxation techniques; examine external stressors and internal triggers; and prepare for life after the intervention. Participants will be asked to complete weekly homework, thought records, seizure logs that are found in their workbooks and to engage in journal entries.
Primary outcomes
- Enrollment rate (post intervention (14 weeks after baseline))
- Retention rate (post intervention (14 weeks after baseline))
- Session attendance rate (proportion of sessions attended) (post intervention (14 weeks after baseline))
- Homework completion rate (proportion of homework assignments completed) (post intervention (14 weeks after baseline))
- User satisfaction as assessed by The Participant Satisfaction Survey (post intervention (14 weeks after baseline))
Eligibility information
Inclusion Criteria:
* English speaking veterans
* has home internet access
* has access to and familiarity in using a computer or tablet at least weekly
* Asymptomatic patients with chronic conditions
* has access to a mobile device with Short Message Service (SMS) text and picture capability
* has an active clinical diagnosis of major depressive disorder based on the International Classification of Diseases, 10th version (ICD-10)
* has an ICD-10 diagnosis of epilepsy with at least one seizure documented within the last five years
Exclusion Criteria:
* pregnancy
* Veterans that have current suicidal ideation
* have active psychosis; and have an ICD-10 diagnosis of psychogenic non-epileptic seizures or conversion disorder.
Study locations
- Michael E. DeBakey VA Medical Center, Houston, Texas 77030 United States
- The University of Texas health Science Center at Houston, Houston, Texas 77030 United States
Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.