Recruiting
Neurosurgical Outcome Network
The evaluation of neurosurgical outcomes varies from center to center, and the predictive factors that determine these outcomes are not fully known or shared. This study aims to assess outcomes and their predictors using measures agreed upon by the participating centers. Standardizing the evaluation of outcomes and predictors improves the quality of research, allows for data comparison, and facilitates a "common language" in routine clinical practice. Most importantly, it influences therapeutic decisions in…
ClinicalTrials.gov IDNCT06724029
PhaseNot Applicable
Enrollment4500
SponsorFondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Age18 Years
SexALL
Conditions studied
Aneurysms, Arteriovenous Malformations, Cavernomas, Skull Base Tumors, Moyamoya Disease, Dural Fistulas, Subdural Hematoma, Extradural Hematoma, Subarachnoid Hemorrhage, Hydrocephalus, Parkinson&Amp;#39;s Disease, Spasticity, Trigeminal Neuralgia, Craniofacial Pain, Neuropathic Pain, Tremor, Dystonias, Obsessive-compulsive Disorder, Drug-resistant Epilepsy, Depression, Normal Pressure Hydrocephalus, Tumors of Peripheral Nerves, Chiari Malformation Type 1
About this study
The evaluation of neurosurgical outcomes varies from center to center, and the predictive factors that determine these outcomes are not fully known or shared. This study aims to assess outcomes and their predictors using measures agreed upon by the participating centers. Standardizing the evaluation of outcomes and predictors improves the quality of research, allows for data comparison, and facilitates a "common language" in routine clinical practice. Most importantly, it influences therapeutic decisions in various neurosurgical conditions. Clinically, the identified predictors can also be used during preoperative assessments to provide more precise guidance to patients undergoing surgery.
Primary outcomes
- Collect data (5 years)
- Collection data (5 years)
- Collection data (5 years)
Eligibility information
Inclusion Criteria:
* Neuro-oncological pathology: supratentorial and subtentorial tumors, intra and extra axial tumors excluding the skull base (anterior, middle and posterior fossa; sellar and parasellar region)
* Basicranial pathology: tumors originating from the anterior cranial fossa, middle cranial fossa and posterior cranial fossa, sellar region with or without supratentorial/parasellar development.
* Vascular pathology: aneurysms, AVMs, cavernomas, other pathologies (Moyamoya disease, dural fistulas, nontraumatic hematomas)
* Traumatic pathology: diffuse damage (nonvisible diffuse damage, diffuse damage, diffuse damage with edema, diffuse damage with shift) and focal damage (acute/subacute/chronic subdural hematoma, extradural hematoma, subarachnoid hemorrhage, intraparenchymal hematoma, fractures); hydrocephalus. The inclusion criterion for chronic subdural hematoma is recent bleeding for TBI with CT finding of chronic subdural hematoma candidate for evacuation surgery.
* Spinal pathology: degenerative cervical (anterior/posterior), myelopathic, and trauma pathology; instrumented, uninstrumented thoracolumbar pathology (disc pathology, canal pathology), and trauma pathology; oncologic spinal pathology.
* Functional pathology: Parkinson's disease, spasticity, trigeminal neuralgia, craniofacial pain/algia, neuropathic pain, tremor, dystonias, obsessive compulsive disorder, drug-resistant epilepsies, depression. Normotensive hydrocephalus.
* Peripheral nervous system pathology: peripheral nerve compression syndromes, peripheral nerve and plexus tumors, brachial plexus and peripheral nerve trauma (contusion and section)
* Malformative pathology: Chiari malformation type 1 and craniostenoses including both those framed in malformative syndromes and those not framed in malformative syndromes (monosutural craniostenoses: trigonocephaly, plagiocephaly, scaphocephaly; multisutural craniostenoses). Malformative hydrocephalus.
* For cognitive and psychological assessment: age 18 years or older; adequate understanding of Italian language; diagnosis of glioma, meningioma, vascular pathology, spinal pathology
Exclusion Criteria:
* For cognitive and psychological assessment: patients with psychiatric diseases in history and/or taking psychotropic drugs; presence of overt cognitive decline (not due to the injury) in history; patients younger than 18 years old.
Study locations
- 1. ASST Papa Giovanni XXIII, Bergamo, BG 24127 Italy
- Spedali Civili Brescia, Brescia, BS 25123 Italy
- Fondazione Poliambulanza Istituto Ospedaliero, Brescia, BS 25124 Italy
- Ospedale Moriggia Pelascini, Gravedona, Como 22015 Italy
- ASST Lariana, Ospedale S. Anna, Como, CO 22100 Italy
- ASST Cremona, Cremona, CR 26100 Italy
- Fondazione IRCCS San Gerardo dei Tintori, Monza, MB 20900 Italy
- Fondazione IRCCS Policlinico San Matteo, Pavia, PV 27100 Italy
- ASST della Valtellina ed Alto Lario, Sondrio, SO 23100 Italy
- Azienda Ospedaliero Universitaria Policlinico "G. Rodolico - San Marco", Catania, Italy
Showing 10 of 27 reported sites. See the official listing for all locations.
Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.