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Wild Blueberries for Gut, Brain, and Heart Health in Adults With High Blood Pressure

The purpose of the study is to determine the effectiveness of wild blueberries on cardiovascular health, cognitive function, and gut microbiota composition in non-Hispanic Black and White adults with elevated blood pressure.

ClinicalTrials.gov IDNCT06735599

PhaseNA

Enrollment40

SponsorGeorgia State University

Age45 Years

SexALL

I'm interested View official listing

Conditions studied

Hypertension (Without Type 2 Diabetes Mellitus), High Blood Pressure, Male, Female, Adult, Cognition, Endothelial Function (Reactive Hyperemia), Oxidative Stress, Diet, Overweight, Body Composition Measurement, Gut Microbiome, Arterial Stiffness, Caucasian Whites, Inflammation, Microvascular Function

About this study

Interventions

Dietary Supplement: Wild Blueberry — Daily consumption of 22 g of freeze-dried wild blueberry freeze-dried powder for 8 weeks
Dietary Supplement: Placebo — Daily consumption of 22 g of freeze-dried macronutrient-matched placebo powder for 8 weeks

Primary outcomes

Ambulatory Blood Pressure (Baseline, 4 weeks, and 8 weeks)
Pulse Wave Velocity (Baseline, 4 weeks, and 8 weeks)

Eligibility information

Inclusion Criteria: * Individuals 45-65 years of age * Diagnosis of elevated blood pressure or stage 1 hypertension (systolic blood pressure = 120-139 mmHg and/or diastolic blood pressure = 80-89 mmHg) for at least 6 months * BMI 25-35 kg/m2 via anthropometric measurements. * Ability to give consent Exclusion Criteria: * Allergies to berries * Use of one hypertensive drug for less than three months * Use of more than one anti-hypertensive or statin drug, insulin, antibiotics, and anti-inflammatory drugs, active cancer, gastrointestinal, renal, cardiovascular, thyroid, and neurological disorders or severe head injury * Smoking * Alcohol consumption (\>2 drinks/day) * Consuming antioxidant, probiotic, and prebiotic supplements * Pregnant or lactating * Participating in a weight loss program

Study locations

Georgia State University, Atlanta, Georgia 30303 United States

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.