Recruiting

Orexin Gene in Anorexia Nervosa

The objectives of this study will be to determine the methylation of the promoter of the Orexin A (OX-A) and B (OX-B) genes in young women (\> 18 years) with Anorexia Nervosa (AN), compared with a control group; and to evaluate the relationship of promoter methylation of the genes for OX-A and OX-B with the severity of the eating disorder, psychiatric comorbidities (in particular, depression), and sleep quality.

ClinicalTrials.gov IDNCT06800898

PhaseNot Applicable

Enrollment60

SponsorIstituto Auxologico Italiano

Age18 Years

SexFEMALE

I'm interested View official listing

Conditions studied

Anorexia Nervosa

About this study

Interventions

Other: Blood samples and Questionnaires — Blood samples for methylation of the promoter of the OX-A and OX-B genes and questionnaires: Eating Disorder Examination Q Eating Disorder Inventory 3 Major Depression Inventory Symptom Checklist-revised ESS - Epworth Sleepiness Scale Pittsburgh Sleep Quality Index Horne \& Ostberg questionnaire

Primary outcomes

Orexin A promoter methylation (Baseline)
Orexin B promoter methylation (Baseline)

Eligibility information

Patients with Anorexia Nervosa: Inclusion Criteria: * Female sex * Age 18 years and older * Anorexia Nervosa * Hospitalized at the Division of Eating and Nutrition Disorders, Istituto Auxologico Italiano, IRCCS, Piancavallo, Italy Exclusion Criteria: * Absence of signed informed consent Control group: Inclusion Criteria: * Female sex * Age 18 years and older * Body Mass Index between 18.5 and 24.9 kg/m2 Exclusion Criteria: * Absence of signed informed consent * Presence of any physical and mental pathology

Study locations

Istituto Auxologico Italiano IRCCS, Site Piancavallo, Oggebbio, Verbania 28824 Italy

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.