Recruiting

Anti-hypertensive Therapy and Exercise Treatment to Improve Vascular Health in Patients With Hypertension.

This is a prospective, monocentric, randomized controlled trial to investigate the effect of anti-hypertensive treatment and/or individualized exercise training intervention on blood pressure and vascular health. Furthermore the investigators want to decipher mechanisms, which contribute to vascular health by analyzing changes in metabolism and cell function in relation to vascular reaction.

ClinicalTrials.gov IDNCT06823570

PhaseNA

Enrollment60

SponsorHeinrich-Heine University, Duesseldorf

Age18 Years

SexALL

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Conditions studied

Hypertension, Vascular Function, Fitness Testing, Metabolism Changes

About this study

Interventions

Behavioral: Individualized exercise therapy — Patients in the intervention group will receive an individualized exercise training program 3x/week.
Behavioral: Lifestyle recommendations — The lifestyle recommendation group will receive general recommendations such as salt reduction, higher physical activity levels and stress reduction.

Primary outcomes

The additional effect of an anti-hypertensive treatment plus an individualizes exercise therapy on the retinal vessel diameters compared to a guideline based anti-hypertensive treatment with general lifestyle recommendations. (From enrollment to the end of treatment after six month.)
Effect of an guideline based anti-hypertensive therapy on the retinal vessel diameters. (From enrollment to the end of treatment after six month.)

Eligibility information

Inclusion Criteria: \- systolic hypertension grade I-II (BP values \>140 mmHg to \<180 mmHg) without anti-hypertensive medication treatment Exclusion Criteria: * no written informed consent * age \<18 years * isolated diastolic hypertension * medical contraindications for the exercise treatment (for example orthopedic problems or an abnormal ECG during the cardio respiratory exercise test) * chronic eye diseases on both eyes (for example macular degeneration or glaucoma) or high intraocular pressure (\>20 mmHg)

Study locations

Universitätsklinik Düsseldorf, Düsseldorf, Düsseldorf 40225 Germany

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.