Recruiting

Sleep TMS for Depression

The goal of this study is to establish the feasibility, tolerability, and preliminary efficacy of sleep-state transcranial magnetic stimulation (TMS) for enhancing plasticity in depression treatment.

ClinicalTrials.gov IDNCT06824415

PhaseNA

Enrollment55

SponsorStanford University

Age18 Years

SexALL

I'm interested View official listing

Conditions studied

Major Depression, Sleep

About this study

The goal of this study is to establish the feasibility, tolerability, and preliminary efficacy of sleep-state transcranial magnetic stimulation (TMS) for enhancing plasticity in depression treatment.

Interventions

Device: TMS — Transcranial magnetic stimulation (TMS) applies magnetic pulses to stimulate nerve cells in the brain.

Primary outcomes

Change in Baseline TMS-EEG after iTBS (Baseline, end of iTBS (3 minutes))
Change in Baseline TMS-EEG after NREM Sleep (Baseline, end of sleep stage (3 hours))
Change in N-back Accuracy Performance (Baseline, end of sleep stage (3 hours))
Change in N-back Reaction Time Performance (Baseline, end of sleep stage (3 hours))
Change in MSIT Accuracy Performance (Baseline, end of sleep stage (3 hours))
Change in MSIT Reaction Time Performance (Baseline, end of sleep stage (3 hours))

Eligibility information

Inclusion Criteria: * Adults ages 18-65 years * Current Major Depressive Disorder (MDD) diagnosis * Failed ≥1 antidepressant medication * Moderate-to-severe depression * Stable antidepressant medication dose for ≥ 6 weeks prior to enrollment * Healthy control participants are adults ages 18-65 years without current MDD symptoms, not taking antidepressant or antipsychotic medications, and without major psychiatric, neurological, substance use, medical conditions affecting brain function, or TMS/MRI contraindications. Exclusion Criteria: * Intellectual disability * Significant head injury/neurological disorder * Pregnancy or postpartum * TMS/MRI contraindications * Active substance use/suicidal ideation

Study locations

Stanford University, Stanford, California 94305 United States

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-10-01.