Recruiting
Peanuts for Cardiometabolic, Brain, and Intestinal Health
The overall objective of this 14-month randomized crossover study is to seek evidence demonstrating that daily consumption of peanuts and peanut products improve cardiometabolic, cognitive, and intestinal health in a racially diverse prediabetes population.
ClinicalTrials.gov IDNCT06867198
PhaseNA
Enrollment72
SponsorGeorgia State University
Age20 Years
SexALL
Conditions studied
Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Cognition, Microvascular Function, Gut Microbiota, Endothelial Function (Reactive Hyperemia), Arterial Stiffness, Blood Pressure, Adult
About this study
The overall objective of this 14-month randomized crossover study is to seek evidence demonstrating that daily consumption of peanuts and peanut products improve cardiometabolic, cognitive, and intestinal health in a racially diverse prediabetes population.
Interventions
- Dietary Supplement: Peanuts — 43 g of peanut butter (1 snack cup) 3 x/week, 42 g of dry roasted peanuts (1/3 of a cup) 3x/week, or 56 g of peanut flour 1x/week for 6 months.
Primary outcomes
- Blood Glucose (Baseline, 3 months, and 6 months)
- Glycosylated hemoglobin (Baseline, 3 months, and 6 months)
Eligibility information
Inclusion Criteria:
* men and women
* 20-59 years of age
* BMI: 24.5 - 35.5 kg/m\^2
* Prediabetes (fasting blood glucose levels 100-125 mg/dL and/or HbA1c between 5.7-6.4%)
* Ability to give consent
Exclusion Criteria:
* Allergies to peanuts and peanut products
* Use of insulin, antidiabetic, antibiotics, and anti-inflammatory drugs
* Active cancer, gastrointestinal, renal, cardiovascular, thyroid, and neurological diseases or severe head injury
* Smoking
* Consumes greater than 2 alcoholic beverages per day
* Consumes antioxidant, probiotic, and prebiotic supplements
* Pregnant or Lactating
* Actively participating in a weight loss program
MRI Exclusion Criteria:
* Certain neurological disorders (e.g., uncontrolled seizure disorders)
* Braces on their teeth, a cardiac pacemaker; hearing aid; other metal in the body or eyes (which may include certain metallic-embedded tattoos), including but not limited to pins, screws, shrapnel, plates, dentures or other metal objects
Study locations
- Georgia State University, Atlanta, Georgia 30303 United States
Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-30.