Study on Blood Pressure Variability and Frailty in the Older People
Observational prospective single-center, non-profit study. Primary objective of the study: To determine if the hypotensive phenotype, defined as one episode of daytime systolic blood pressure (SBP) \<90 mmHg (or two episodes of daytime SBP \<90 mmHg, if mean 24 h SBP is \<125 mmHg) detected at Ambulatory Blood Pressure Monitoring (ABPM) is associated with adverse events at follow up (death, hospitalization, falls, emergency room admission for uncontrolled hypertension, major cardiovascular events)
Conditions studied
Hypertension, Old Age
About this study
Observational prospective single-center, non-profit study. Primary objective of the study: To determine if the hypotensive phenotype, defined as one episode of daytime systolic blood pressure (SBP) \<90 mmHg (or two episodes of daytime SBP \<90 mmHg, if mean 24 h SBP is \<125 mmHg) detected at Ambulatory Blood Pressure Monitoring (ABPM) is associated with adverse events at follow up (death, hospitalization, falls, emergency room admission for uncontrolled hypertension, major cardiovascular events)
Interventions
- Diagnostic Test: Diagnostic tests and questionnaires — Assessment of office blood pressure, orthostatic hypotension, 24-hour ambulatory blood pressure, frailty
Primary outcomes
- Incidence of adverse events (At 24 months of follow-up)
- Prevalence of hypotensive phenotype (At baseline)
Eligibility information
Study locations
- Istituto Auxologico Italiano IRCCS, Milan, 20145 Italy
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-10-26.