Multimodal Monitoring Study in Neuro Critical Care

Conditions studied

Subarachnoidal Hemorrhage, Intacranial Hypertension, Acute Trauma Brain Injury

About this study

During the first week after an acute cerebral injury, neurologic clinical exam is often irrelevant, limited by sedation use or spontaneous consciousness disorders. Hence, neurological monitoring of brain oxygen consumption, metabolic disorders, electrical activity is used to follow and prevent delayed cerebral injuries. Among those instruments, numerous are often described: intra cranial pressure monitoring, brain tissue oxygen pressure monitoring, scalp electroencephalography, continuous electroencephalography and Near infrared Red Spectroscopy (NIRS). Even if the value of some of those technologies are well known, many remain part of a research domain. Here we will not only try to study the correlation between different cerebral autoregulation's index described in the scientific literature but also will we try to identify and describe EEG and cardiorespiratory changes during the first week following brain injury. The objective of this study is to investigate the pathophysiology of acute brain injury and explore potent biomarkers of multimodal monitoring during the first week following acute brain injury.

Interventions

• Other: Study the evolution and correlation between cerebral autoregulation index — Objective n°1: Study the correlation between autoregulation index: The investigators will look for a correlation between several auroregulation index such as the PRx, ORx and Cox. Objective n°2: Evaluation and detection of EEG prognostic patterns: The investigators will look for quantitaive EEG changes during the early phase of acute brain injuries.

Primary outcomes

• Correlation between ORx and PRx (Multimodal neuro monitoring is used from 1 to 15 days after the acute brain injury.)

Eligibility information

Study locations

• Hopital Pierre Wertheimer, France, Bron 69500 France