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Test of Target Engagement of Ambiguity Aversion
The present work aims to test whether a single session intervention alters ambiguity aversion, both in terms of people's decision making and their brain responses to ambiguous choices.
ClinicalTrials.gov IDNCT06962527
PhaseNA
Enrollment140
SponsorNorthwestern University
Age25 Years
SexALL
Conditions studied
Intolerance of Uncertainty, Anxiety, Intolerance of Uncertainty; Anxiety, Depression, Anxiety
About this study
The present work aims to test whether a single session intervention alters ambiguity aversion, both in terms of people's decision making and their brain responses to ambiguous choices.
Interventions
- Behavioral: Uncertainty-focused single session intervention — Digitally/computer administered 30-minute self-guided intervention for adults ages 25-60
- Behavioral: Maintaining a healthy lifestyle single session intervention — Digitally/computer administered 30-minute self-guided intervention for adults ages 25-60
Primary outcomes
- Beck Hopelessness Scale-4 (BHS-4) (1 hour)
- Behavioral ambiguity aversion (1 hour)
- Event-related potential responses to ambiguous choices (1 hour)
Eligibility information
Inclusion Criteria:
1. Ages 25 to 60
2. Right-handed
3. Ability to read and write English
4. Capacity to provide informed consent
5. Intolerance of uncertainty score ≥ -0.5 standard deviation below the mean (31st percentile)
Exclusion Criteria:
1. Personal history of psychosis, mania, or hypomania
2. Personal history of autism spectrum disorder
3. IQ \< 80 as determined by the Wechsler Test of Adult Reading
4. Head injury with greater than 120 seconds loss of consciousness
5. Neurological condition (e.g., epilepsy, Parkinson's, cerebral palsy, history of stroke)
6. Currently pregnant
7. Use of any implanted electrical device (e.g., pacemaker, spinal stimulator, vagal nerve stimulator, Inspire sleep apnea device, etc.).
Study locations
- Northwestern University, Chicago, Illinois 60611 United States
Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.