The Combined First Trimester Screening

Conditions studied

Preeclampsia (PE), Fetal Growth Restriction, Congenital Abnormalities, Preterm Labor, Intrauterine Fetal Demise, Genetics Syndrome, Pregnancy Overdue - Week 41+6

About this study

The project is a national, prospective, multicenter pilot project. The project is focus on setting up the combined first trimester screening in the Czech Republic. The combined first trimester screening is aimed at predicting and detecting the most serious obstetric complications, such as the great obstetrical syndromes (preeclampsia, fetal growth restriction, preterm labor and intrauterine fetal demise "IUFD") and structural congenital defects (morphological and chromosomal). The primary objective of the project is to create a unified methodology for performing and evaluating the combined first trimester screening in connection with the National Health Information System (hereinafter referred to as "NHIS"), which will enable recording, providing analysis and linking recorded clinical parameters with data in the NHIS. The pilot project will also provide data for modeling appropriate mechanisms for reimbursement from public health insurance.

Primary outcomes

• Proportion of women with identified increased risk of Preeclampsia, Fetal Growth Restriction or Fetal Chromosomal Aneuploidies (trisomies of chromosomes 21, 18 and 13) (From June 2025 to October 2026)

Eligibility information

Study locations

• Regional Health Corpotarion - Most Hospital, Most, Czechia Czechia
• University Hospital Olomouc, Olomouc, Czechia Czechia
• Institute for the Care of Mother and Child, Prague, Czechia Czechia