Clinical trials / NCT07031102
Recruiting

Methacholine Challenge Test in School Children With/Without Asthma RISKA

The study includes a pre-study telephone interview with healthy controls to assess their eligibility for participation. During the study visit, a background information form and an asthma questionnaire are completed. At the study visit, a methacholine challenge test measuring airway hyperresponsiveness and an exhaled nitric oxide measurement are performed. The effect of medication intensification in asthma patients is further assessed through a telephone interview 1-2 months after the medication adjustment.

ClinicalTrials.gov IDNCT07031102
PhaseNot Applicable
Enrollment260
SponsorHelsinki University Central Hospital
Age7 Years
SexALL
I'm interested View official listing

Conditions studied

Asthma Bronchiale, Lung Function Tests, Bronchial Hyperresponsiveness

About this study

The study includes a pre-study telephone interview with healthy controls to assess their eligibility for participation. During the study visit, a background information form and an asthma questionnaire are completed. At the study visit, a methacholine challenge test measuring airway hyperresponsiveness and an exhaled nitric oxide measurement are performed. The effect of medication intensification in asthma patients is further assessed through a telephone interview 1-2 months after the medication adjustment.

Primary outcomes

Eligibility information

Inclusion Criteria: Healthy Controls * • Aged 7-15 years, both sexes * No diagnosis of asthma in childhood * No inhaled asthma medication during the previous 2 years * No wheezing or shortness of breath during the previous 2 years * Written informed consent from the participant and guardian Inclusion Criteria: Children with Asthma * Aged 7-15 years, both sexes * Physician-diagnosed asthma (ICD-10 codes J45.0/J45.1/J45.9) * Inhaled corticosteroid treatment for at least 6 months * Either: * Well-controlled asthma (c-ACT/ACT score ≥20) and no clinical need to intensify medication, or * Poorly controlled asthma with physician-confirmed need for intensified asthma medication Exclusion Criteria: * • Premature birth before 32 gestational weeks * Other chronic cardiopulmonary or neurological conditions affecting airways (excluding asthma) * Severe underlying illness such as malignancy * Beta-blocker medication * Active immunological disease

Study locations

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-28.