Recruiting
Arterial Stiffness in Individuals With Breast Cancer
The aim of this study was to evaluate vascular toxicity induced by anthracyclines and other anticancer drugs and to measure arterial stiffness in women with breast cancer and, in addition, to evaluate the acute and chronic arterial stiffness responses of upper extremity aerobic exercise training.
ClinicalTrials.gov IDNCT07070778
PhaseNA
Enrollment18
SponsorHacettepe University
Age40 Years
SexFEMALE
Conditions studied
Aerobic Exercise, Breast Cancer, Arterial Stiffness
About this study
The aim of this study was to evaluate vascular toxicity induced by anthracyclines and other anticancer drugs and to measure arterial stiffness in women with breast cancer and, in addition, to evaluate the acute and chronic arterial stiffness responses of upper extremity aerobic exercise training.
Interventions
- Other: Upper Extremity Aerobic Exercise Training Program — 12 weeks of supervised upper limb aerobic exercise training, 3 sessions per week, 25 minutes per session.
Primary outcomes
- Arterial Stiffness (one years)
Eligibility information
Inclusion Criteria:
* To be between the ages of 40-69,
* Baseline left ventricular ejection fraction (LVEF) \>50%,
* Absence of coronary artery disease and haemodynamically significant valvular heart disease,
* Absence of carotid atherosclerotic plaques,
* Volunteering to participate in the research,
* At least 15 months after breast cancer surgery,
* No problems in reading and/or understanding the scales and being able to co-operate with the tests.
* Physically inactive (60 minutes of structured exercise per week \<).
Exclusion Criteria:
* Presence of active infection,
* Presence of bilateral breast cancer,
* History of surgical, neurological or orthopaedic problems that may affect upper extremity functionality other than breast cancer surgery,
* Having a neurological disease or other clinical diagnosis that may affect cognitive status,
* Left ventricular dysfunction and severe liver and kidney dysfunction before starting chemotherapy
* Musculoskeletal and neurological disease that may affect exercise performance, symptomatic heart disease, previous lung surgery and malignant disease.
* Presence of unstable hypertension or diabetes mellitus.
Study locations
- Hacettepe University, Ankara, State 06100 Turkey (Türkiye)
Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.