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PH-DyPred: A Multimodal Dynamic Risk Prediction Study in Pulmonary Hypertension

Pulmonary hypertension (PH) is a progressive cardiopulmonary disease characterized by elevated pulmonary artery pressure and vascular remodeling, which leads to right heart failure and increased mortality. Despite advances in diagnostics, risk stratification remains limited due to the disease's heterogeneity. This study aims to develop and validate a dynamic risk prediction model for PH by integrating multimodal data-including echocardiography, Cardiac MRI, PET-MR, ECG, biomarkers, and clinical features-using…

ClinicalTrials.gov IDNCT07131241
PhaseNot Applicable
Enrollment1000
SponsorFirst Affiliated Hospital of Fujian Medical University
Age18 Years
SexALL
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Conditions studied

Pulmonary Hypertension

About this study

Pulmonary hypertension (PH) is a progressive cardiopulmonary disease characterized by elevated pulmonary artery pressure and vascular remodeling, which leads to right heart failure and increased mortality. Despite advances in diagnostics, risk stratification remains limited due to the disease's heterogeneity. This study aims to develop and validate a dynamic risk prediction model for PH by integrating multimodal data-including echocardiography, Cardiac MRI, PET-MR, ECG, biomarkers, and clinical features-using advanced machine learning algorithms. The study will establish a prospective cohort of PH patients to explore predictive markers, stratify prognosis, and provide a scientific basis for early warning and individualized management.

Primary outcomes

Eligibility information

Inclusion Criteria: * Adults aged 18 years or older * Pulmonary artery systolic pressure (PASP) ≥35 mmHg as estimated by echocardiography * Provided written informed consent Exclusion Criteria: * Severe hepatic or renal insufficiency * Malignancy under active treatment * Severe infection * Active autoimmune disease * Major surgery within the past 3 months * Pregnant or breastfeeding women * Severe psychiatric disorder impairing ability to comply with the study protocol

Study locations

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.