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Trajectories of Anxiety and Depression in Cancer Patients, Risk and Predictive Factors and Supportive Care; Prognostic Awareness and Shared Decision Making.

To examine the trajectories of anxiety and depression symptoms over the course of oncological disease, and to assess potential predictors-sociodemographic (age, sex, marital status, employment status), clinical (tumor location, stage, treatment type, general health), psychological (coping strategies, quality of life, cognitive difficulties, fear of recurrence), and physical activity-and their association with support needs and utilization of psychosocial services.

ClinicalTrials.gov IDNCT07168096

PhaseNot Applicable

Enrollment540

SponsorFundación Sociedad Española de Oncologia Médica

Age18 Years

SexALL

I'm interested View official listing

Conditions studied

Depression, Cancer, Anxiety

About this study

Interventions

Other: Psychosocial and clinical assessment — Participants complete standardized self-report questionnaires and undergo medical record review at three time points (baseline, 3 months, and 6 months) to assess psychological symptoms (anxiety, depression, somatization), coping strategies, quality of life, cognitive difficulties, physical activity, nutrition, supportive care needs, and informed decision-making in the context of cancer treatment. No experimental treatment or therapy is administered.

Primary outcomes

Anxiety and depression symptoms (At the time of diagnosis or treatment initiation. Follow-up at 3 months: To assess the early evolution of symptoms. Follow-up at 6 months: To analyze the medium-term evolution.)

Eligibility information

Inclusion Criteria: * Histologically confirmed diagnosis of solid cancer (non-hematologic) at any stage. * Adult age (\>18 years). * Candidate for perioperative systemic antineoplastic treatment or for advanced disease. * Willingness to participate in the study and sign the informed consent form, as appropriate, before initiating any study-specific procedures, in accordance with good clinical practice requirements and local regulations. Exclusion Criteria: * Presence of a pre-existing psychiatric or neurodegenerative disorder that impairs the patient's ability to participate in the study. * Presence of reading and writing difficulties that prevent the patient from completing the assessments. * Receipt of oncological treatment in the past 2 years for another cancer.

Study locations

Hospital Universitario Marqués de Valdecilla, Santander, Cantabria 39008 Spain
Hospital General Universitario de Ciudad Real, Ciudad Real, Ciudad Real 13005 Spain
Hospital Universitario Virgen de la Luz, Cuenca, Cuenca 16002 Spain
Hospital General Universitario de Elche, Alicante, Elche 03203 Spain
Hospital Universitario del Sureste, Arganda, Madrid 28500 Spain
Hospital Universitario La Paz, Fuencarral-El Pardo, Madrid 28046 Spain
Hospital Universitario Fuenlabrada, Fuenlabrada, Madrid 28942 Spain
Hospital Universitario de La Princesa, Salamanca, Madrid 28006 Spain
Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid 28702 Spain
Hospital Universitario Infanta Leonor, Vallecas, Madrid 28031 Spain

Showing 10 of 18 reported sites. See the official listing for all locations.

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.