Recruiting

Optimizing the AYA Survivors' Coping and Emotional Needs Toolkit

Our team has developed a digital intervention that aims to help adolescent and young adult cancer survivors (AYAs) manage symptoms of depression. This tool includes one psychoeducation component and four components that are based on evidence-based interventions for depression. The goal of this study is to test which component or combination of components meaningfully contribute to improvements in depressive symptoms among AYAs.

ClinicalTrials.gov IDNCT07173205

PhaseNA

Enrollment208

SponsorEast Carolina University

Age15 Years

SexALL

I'm interested View official listing

Conditions studied

Depression, Cancer, Adolescent, Young Adult, Adult

About this study

Interventions

Behavioral: AYA Survivors Coping and Emotional Needs Toolkit (ASCENT) — Participants will receive access to a digital depression self-management tool (ASCENT), which aims to help AYAs manage symptoms of depression post-treatment. All users will have access to the core tool which includes daily mood tracking and a psychoeducational module about cancer and depression. Depending on assigned condition, participants will also receive access to up to 4 intervention modules which have been adapted from existing evidence-based treatments for digital delivery to AYAs through a rigorous user-centered design process. Within each module there are 6 micro-lessons that include an educational video, a real story from an AYA that demonstrates the topic, multiple choice questions that ask the participant to apply the educational information to the AYA story, open-ended questions that ask the participant to apply the educational information to their own experience, and a practice activity in which they are asked to try out a relevant skill.

Primary outcomes

Change in Depressive Symptoms during Intervention Period (Baseline to Week 6)

Eligibility information

Inclusion Criteria: * Age at enrollment (adolescents 15-17, emerging adults 18-25, young adults 26-39) * Age at diagnosis (adolescents 12-17, emerging adults 15-25, young adults 15-39) * Time since completion of treatment: 1 month to 5 years * Language: Fluent in English (spoken and written) * Technology: Own smart phone with data plan Exclusion Criteria: * Mental Health: Current diagnosis of severe or persistent mental illness * Suicidality: Severe suicidal ideation (including plan and intent)

Study locations

East Carolina University, Greenville, North Carolina 27858 United States
Wake Forest University, Winston-Salem, North Carolina 27109 United States

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-30.