Recruiting
Intervention Effect of Temporal Interference Stimulation (TIS) on Depressive Disorder
To investigate the effect of Temporal Interference Stimulation (TIS) on associative memory (AM) in patients with depressive disorder
ClinicalTrials.gov IDNCT07191392
PhaseNA
Enrollment60
SponsorThe Second Hospital of Anhui Medical University
Age12 Years
SexALL
Conditions studied
Depressive Disorder, Temporal Interference Stimulation
About this study
To investigate the effect of Temporal Interference Stimulation (TIS) on associative memory (AM) in patients with depressive disorder
Interventions
- Device: Temporal Interference Stimulation (TIS) — The total stimulation duration was 30 minutes, including a 30-second current ramp-up at the beginning and a 30-second ramp-down at the end.
- Device: Sham temporal interference stimulation (TIS) — Sham stimulation had only 30 seconds of current ramping-up and ramping-down at the beginning and end of the stimulation, respectively, to simulate the sensation of actual stimulation
Primary outcomes
- face-word assciative memory task score (baseline and immediately after the intervention)
- Change in Hamilton Depression Rating Scale (HAMD) Score (baseline and immediately after the intervention)
- Change in the Patient Health Questionnaire-15 (PHQ-15) scale (baseline and immediately after the intervention)
Eligibility information
Inclusion Criteria:
* the patients were diagnosed by more than 2 psychiatrists and met the diagnostic criteria of DSM-5 for depression, and HAMD\>17, BSS\>6, PHQ-15\>5.
* the age ranged from 18 to 65 years old, and the length of education was more than 5 years.
* the visual acuity or corrected visual acuity is normal, right-handed, can cooperate with the completion of various experimental tests.
Exclusion Criteria:
* accompanied by severe somatic diseases, such as severe heart, liver, renal insufficiency and so on.
* accompanied by other neurological diseases, such as stroke, epilepsy and so on. pregnant and lactating women.
* accompanied by other mental disorders, such as drug abuse, schizophrenia, schizophrenic affective
Study locations
- Anhui Medical University, Hefei, Anhui China
- Anhui Mental Health Center, Hefei, Anhui China
Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.