Recruiting

Feasibility of Aerobic Exercise With Blood Flow Restriction Training in People Living With Type 2 Diabetes

ClinicalTrials.gov IDNCT07196371

PhaseNA

Enrollment60

SponsorUniversity of New Brunswick

Age19 Years

SexALL

I'm interested View official listing

Conditions studied

Type 2 Diabetes

About this study

The goal of this trial is to learn if blood flow restriction training with treadmill walking is possible for individuals living with type 2 diabetes. It will also learn about how the blood flow restriction with treadmill walking could improve health. The main questions it aims to answer are: Is 6 weeks of treadmill walking with blood flow restriction reasonable for people with type 2 diabetes to perform? Does treadmill walking with blood flow restriction training help manage type 2 diabetes better than just treadmill walking? Researchers will compare treadmill walking with blood flow restriction to treadmill walking without blood flow restriction to see if blood flow restriction works to manage type 2 diabetes based on fitness and blood sugar levels. Participants will: Perform treadmill walking with or without blood flow restriction for 96 minutes a week for 6 weeks. Visit the lab before and after the exercise for tests and questionnaires.

Interventions

Behavioral: Aerobic Training with Blood Flow Restriction — Participants will undergo a 6-week aerobic training intervention with blood flow restriction applied to the lower limbs. Blood flow restriction will be applied using a blood pressure cuff set between 60-80% of limb arterial occlusion pressure. Training will consist of treadmill walking at 40-50% of heart rate reserve (HRR) for 32 minutes per session, 3 times per week for a total of 96 minutes per week.
Behavioral: Standard Aerobic Training — Participants will follow the same aerobic training protocol as the AT+BFR group but without blood flow restriction. Training will consist of treadmill walking at 40-50% of HRR for 32 minutes per session, 3 times per week for a total of 96 minutes per week.

Primary outcomes

Rate of Recruitment (Every 4 weeks up to 2 years)
Rate of Enrollment (Every 4 weeks up to 2 years)
Adherence to the Intervention (From enrollment to the end of intervention at week 6)
Rate of Retention for Follow-Up Testing (Every 6 weeks up to 2 years)

Eligibility information

Inclusion Criteria: * Diagnosed with type 2 diabetes (5.7% \< HbA1c \< 9.0%) * Not regularly physically active (150 mins moderate-vigorous physical activity per week) Exclusion Criteria: * Musculoskeletal issues preventing exercise training * Unstable medications over the last 3 months * Absolute contraindications to BFR (i.e. peripheral vascular disease) * A self-reported diagnosis of low iron concentrations, anemia, or being treated for these conditions * A diagnosis of any red blood cell-altering condition (i.e., sickle cell anemia, poikilocytosis) * Currently living with any cardiovascular disease, which would impact the ability to participate in exercise safely * Currently prescribed any medication which would impact the ability to use a heart rate monitor to accurately track intensity

Study locations

Exercise Metabolism and Inflammation Laboratory, Okanagan, British Columbia Canada
Cardiometabolic Exercise & Lifestyle Laboratory, Fredericton, New Brunswick E3B5A3 Canada
Human Performance & Health Research Laboratory, Guelph, Ontario Canada

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.