Recruiting

Timing of Opioid Administration and Postoperative Respiratory Depression.

ClinicalTrials.gov IDNCT07227389

PhaseNot Applicable

Enrollment52

SponsorWayne State University

Age18 Years

SexALL

I'm interested View official listing

Conditions studied

Respiratory Complications, Opioid Induced Respiratory Depression, Postoperative Respiratory Complications

About this study

The goal of this study is to determine if a relationship can be detected between the administration of an opioid and quantitative respiratory depression in spontaneously breathing non-intubated patients who have undergone general anesthesia and have received perioperative opioids. The primary aim is to determine the temporal effect of opioid administration on respiratory depression as assessed by minute ventilation with a reduction of at least 20% in the percent of predicted minute ventilation. A secondary aim is to determine a dose response of opioid administration and its effect on minute ventilation. The investigators aim to determine the influence of opioid administration on minute ventilation on spontaneously breathing patients during post-anesthesia care unit (PACU) stay.

Interventions

Diagnostic Test: Respiratory volume monitoring — Noninvasive continuous respiratory monitoring utilizing bio-impedance to detect tidal volumes, respiratory rate, and minute ventilation.

Primary outcomes

Respiratory interventions 1 (Within 4 hours of patient admittance to Post Anesthetic Care Unit (PACU))
Respiratory interventions 2 (Within 4 hours of patient admittance to Post Anesthetic Care Unit)
Respiratory interventions 3 (Within 4 hours of patient admittance to Post Anesthetic Care Unit)
Respiratory interventions 4 (Within 4 hours of patient admittance to Post Anesthetic Care Unit)

Eligibility information

Inclusion Criteria: * Written informed consent * Adults ≥18 years of age and ≤85 years of age * Patients planned for general anesthesia with an expected anesthetic time of at least 2 hours * Patients expected to receive postoperative opioid analgesia Exclusion Criteria: * Non-operative procedure (imaging) * Patients not admitted to the PACU postoperatively * Use of patient-controlled analgesia systems * Female patients who are pregnant or breastfeeding * Patients with asymmetric lung disease * American Society of Anesthesiologists (ASA) classification V * Emergency surgery (ASA E Modifier)

Study locations

Detroit Medical Center, Detroit, Michigan 48201 United States

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.