Recruiting
Giving Asthmatics Intramuscular Steroids for Preventing Return to the Emergency Department
This study aims to compare the efficacy of a one-time IM dose of dexamethasone versus a 5-day course of prednisone in adult ED patients presenting with asthma exacerbations. This is a randomized, controlled, double-blind, non-inferiority trial conducted at two urban EDs within the Montefiore Health System.
ClinicalTrials.gov IDNCT07228052
PhasePHASE4
Enrollment182
SponsorMontefiore Medical Center
Age18 Years
SexALL
Conditions studied
Asthma
About this study
This study aims to compare the efficacy of a one-time IM dose of dexamethasone versus a 5-day course of prednisone in adult ED patients presenting with asthma exacerbations. This is a randomized, controlled, double-blind, non-inferiority trial conducted at two urban EDs within the Montefiore Health System.
Interventions
- Drug: Dexamethasone 16mg IM — Dexamethasone 16mg Intramuscular Administration Once
- Drug: Prednisone 60mg PO — Prednisone 60mg PO for 5 Days
Primary outcomes
- Asthma Control Test Score (Within 4 Weeks post-discharge, up to 28-30 days)
Eligibility information
Inclusion Criteria:
* Adults ≥18 years old presenting to the ED with an asthma exacerbation
* Diagnosed with asthma per International Classification of Diseases, 10th Revision (ICD-10) criteria or by the treating clinician
* Discharged from the ED with a primary diagnosis of asthma exacerbation
* Initiated systemic corticosteroids during the ED visit
* Must be English or Spanish speaking
Exclusion Criteria:
* Current use of systemic corticosteroids, including Emergency Medical Services (EMS) administration before ED arrival
* History of severe adverse reactions to corticosteroids
* Heart failure and uncontrolled diabetes (glucose \>300mg/dL in the ED)
* Pregnancy or breastfeeding as prednisone is the preferred treatment for asthma in this population
* Inability to provide informed consent
Study locations
- Montefiore Medical Center, The Bronx, New York 10467 United States
Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.