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A Study of Tirzepatide (LY3298176) Compared With Standard of Care in Adult Participants With Obesity and Without Diabetes (SURMOUNT-REAL UK)

The purpose of this study is to evaluate tirzepatide within a real-world setting to assess body weight loss and incidence of type 2 diabetes in adults without diabetes who have obesity and at least one weight-related comorbid condition. Eligible participants must be registered patients at a participating site. Participation in the study will last about 260 weeks.

ClinicalTrials.gov IDNCT07247084

PhasePHASE4

Enrollment3000

SponsorEli Lilly and Company

Age18 Years

SexALL

I'm interested View official listing

Conditions studied

Obesity

About this study

Interventions

Drug: Tirzepatide — Administered SC
Other: Standard of Care — Standard of care

Primary outcomes

Percent Change from Baseline in Body Weight (Baseline, 24 months)

Eligibility information

Inclusion Criteria: * Have a body mass index ≥30 and ≤34.9 kilogram per square meter (kg/m2) * Have an increased waist to height ratio (defined by \>0.5) * Have at least one weight related comorbid condition * Have had at least one attempt to lose weight with lifestyle intervention (diet and physical activity) Exclusion Criteria: * Have type 1 diabetes, type 2 diabetes, or any other types of diabetes * Have had a change in body weight of greater than 5 kilograms (11 pounds) within 90 days prior to screening

Study locations

P91604 St John's Medical Centre, Altrincham, WA14 1PF United Kingdom
P89008 Ashton Medical Group, Ashton-under-Lyne, OL6 6EW United Kingdom
Y02319 SSP Bolton General Practice, Bolton, BL1 4TH United Kingdom
P83012 Tower Family Healthcare, Bury, BL9 0NJ United Kingdom
P91014 Washway Road Medical Centre, Cheshire, M33 7SS United Kingdom
P88007 Cheadle Hulme Medical Group (was Cheadle Hulme Health Centre) (Bridge House), Cheshire, SK8 5LL United Kingdom
Y02790 SSP Bolton Medical Centre, Great Lever, BL3 6PY United Kingdom
P89002 The Brooke Surgery, Hyde SK14, SK14 1AT United Kingdom
P84035 Bodey Medical Centre, Manchester, M14 6WP United Kingdom
P84630 The Arch Medical Practice, Manchester, M15 5TJ United Kingdom

Showing 10 of 30 reported sites. See the official listing for all locations.

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.