Dynamic Airway Resistance & ML: Guide Sputum Suction in Ventilated Patients

Conditions studied

Mechanical Ventilation Pressure High, Ventilator-Associated Pneumonia (VAP), Respiratory Depression Neonatal

About this study

Research has shown that timely suctioning not only improves survival rates but also enhances the quality of life in ventilator-dependent patients. However, clinical judgment on the optimal timing for suctioning currently relies primarily on physician experience, lacking scientific evidence \[10\]. Airway viscous resistance reflects the frictional resistance encountered by gas flow within the airways and is closely associated with airway patency. When airway secretions increase, viscous resistance undergoes dynamic changes. Therefore, analyzing these dynamic variations in viscous resistance derived from ventilator waveforms to determine the optimal suctioning timing and assess its clinical impact on the progression of pulmonary inflammation holds significant scientific value and offers new insights and methodologies for clinical practice.

Interventions

• Procedure: The dynamics of airway resistance — Monitoring the dynamic changes in airway resistance in patients can be used to reflect the progression of pulmonary inflammation and determine the optimal timing for suctioning.
• Diagnostic Test: conventional suctioning — The timing for suctioning is determined based on clinical signs such as rhonchi and an elevated peak pressure.

Primary outcomes

• The drop in airway viscous resistance before and after sputum suction (the process of sputum aspiration(at most 30 minutes))

Eligibility information

Study locations

• The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233000 China
• Peking Union Medical College Hospital, Beijing, Beijing Municipality 100000 China
• the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009 China