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Sodium-rich COndiments Unifying Health and Taste

This research aims to develop an evidence-based classification for sodium-rich condiments (natremic index) based on their CVD-related risks. It is hypothesised that the acute cardiovascular and physiological response (effectively extrapolated to long-term CVD risks) to meals prepared with various sodium-rich condiments can be leveraged upon for the development of such an index that will systematically classify sodium-rich condiments based on the risk they present to cardiovascular health.

ClinicalTrials.gov IDNCT07397754
PhaseNA
Enrollment32
SponsorSingapore Institute of Food and Biotechnology Innovation
Age50 Years
SexALL
I'm interested View official listing

Conditions studied

Elevated Blood Pressure, Vascular Health, Sensory Evaluation

About this study

This research aims to develop an evidence-based classification for sodium-rich condiments (natremic index) based on their CVD-related risks. It is hypothesised that the acute cardiovascular and physiological response (effectively extrapolated to long-term CVD risks) to meals prepared with various sodium-rich condiments can be leveraged upon for the development of such an index that will systematically classify sodium-rich condiments based on the risk they present to cardiovascular health.

Interventions

Primary outcomes

Eligibility information

Inclusion Criteria: 1. ≥ 50, \< 75 years old 2. Male or postmenopausal female (self-reported) 3. ≥ 50 kg body weight 4. Systolic blood pressure (≥ 130, \< 160 mmHg) or diastolic blood pressure (≥ 85, \< 100 mmHg) 5. Willing and able to follow intervention protocol 6. Ability to identify basic tastes (determined by taste discrimination test) 7. English speaking Exclusion Criteria: 1. Prescribed and taking medication which may affect study outcomes (i.e. for blood pressure management, blood thinning etc.) in consultation with study physician (Prof Melvin Leow) and PI(Dr Darel Toh) 2. Type 1 or type 2 diabetes mellitus (i.e. fasting blood glucose ≥ 7.0 mmol/L or HbA1c ≥ 6.5 %) 3. Taking dietary supplements which may affect study outcomes one month prior to their first visit in consultation with study physician, PI and study team 4. Obesity (BMI ≥ 27.5 kg/m2) 5. History or known present diagnosis of hematological (G6PD and coagulation disorders), hepatic (hepatitis B and C), renal, gastrointestional or other relevant disease / disorders which may affect the outcomes of interest in consultation with study physician, PI and study team 6. History of arteriovenous shunt or mastectomy 7. Women who are pregnant, lactating or planning pregnancy 8. History or present diagnosis of HIV and/or tuberculosis 9. History of severe vasovagal syncope (blackouts or near faints) following blood draw 10. Drug abuse within last 5 years 11. Excessive alcoholic beverage consumption \> 2 servings per day (1 serving defined as 360 mL beer, 150 mL wine or 45 mL distilled spirits) 12. Smoking (cigarette, e-cigarette, cigar, pipe, vape) 13. Engaging in habitual vigorous physical activity (as defined by physical activity questionnaire-PAR) 14. Allergic or intolerance to intervention foods. 15. Dislike or unwilling to consume intervention foods 16. Photophobic (sensitivity to intense lights and colours), particularly to intense red lights 17. Has sinus problems problems that affect taste and smell 18. Involvement in other clinical studies that may influence the outcome of the study 19. An ASTAR Staff. 20. A study team member or their immediate family member

Study locations

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-10-01.