Recruiting

Lifestyle Interventions to Prevent cOgnitive Deficits in Subjects With Depressive Symptoms: From mEchanisms to Clinical pRactice

POWER project is a randomized, controlled, non-profit study with the primary objective of testing the effectiveness of non-pharmacological interventions-such as physical activity, cognitive training, and dietary supplementation-in reducing depressive symptoms and preventing or delaying cognitive impairments that frequently co-occur in individuals with Major Depressive Disorder (MDD).

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ClinicalTrials.gov IDNCT07462013

PhaseNA

Enrollment120

SponsorNational Science and Technology Council, Taiwan

Age50 Years – 80 Years

SexALL

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Conditions studied

Major Depressive Disorder (MDD)

About this study

Interventions

Dietary Supplement: Soybean oil (Standard treatment) — 3g/day of Soybean Oil
Dietary Supplement: Eicosapentaenoic acid (omega-3 fatty acid) — 3 grams/day

Primary outcomes

Depressive Symptoms (Weeks 0, 4, 8, 12, 16, 24)
Depressive Symptoms (Weeks 0, 4, 8, 12, 16, 24)
Depressive Symptoms (Weeks 0, 4, 8, 12, 16, 24)
Depressive Symptoms (Weeks 0, 4, 8, 12, 16, 24)
Executive Functioning (Weeks 0, 4, 12, 24)
Executive Functioning (Weeks 0, 4, 12, 24)
Executive Functioning (Weeks 0, 4, 12, 24)
General Cognitive Ability and Memory & Attention (Weeks 0, 4, 12, 24)

Eligibility information

Inclusion Criteria: * Aged 50-80 years old * Major Depressive Disorder * Absence or mild cognitive impairment Exclusion Criteria: \-

Study locations

Mind Body Interface Research Center (MBI Lab & Care), Taichung, Taichung 404 Taiwan

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-10-14.