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Facility-Based Multi-Modal Rehab vs. Home-Based Resistance Exercise for Quality of Life in Breast Cancer Survivors

This study evaluates the comparative effectiveness of a multi-modal facility-based rehabilitation program (therapist-led resistance exercise and relaxation training) versus a self-directed home-based resistance exercise program in post-treatment breast cancer survivors. Participants in both intervention groups will complete a 16-week program consisting of two exercise sessions per week.The multimodal, therapist-led approach is hypothesized to result in superior improvements in physical performance and quality of…

ClinicalTrials.gov IDNCT07465393

PhaseNA

Enrollment66

SponsorValeria Chiu

Age18 Years

SexFEMALE

I'm interested View official listing

Conditions studied

Breast Neoplasms, Sarcopenia

About this study

Interventions

Behavioral: Multimodal Resistance and Relaxation Training — A 16-week multimodal program consisting of resistance exercise and relaxation training. Participants undergo two sessions per week: one weekly session is conducted under the supervision of a physical therapist at Taipei Tzu Chi Hospital, and one weekly session is self-directed and performed by the participant in a home setting. The resistance exercise portion utilizes progressive elastic band training
Behavioral: Home-Based Resistance Exercise Training — A 16-week self-directed resistance exercise program. The intervention consists of two sessions per week performed independently by the participant in a home setting. The exercise regimen utilizes progressive elastic band training and is conducted without direct therapist supervision

Primary outcomes

Change from Baseline in Skeletal Muscle Mass Index (SMI) (16 weeks)

Eligibility information

Inclusion Criteria: * Histologically confirmed primary breast cancer * Stage I-III non-metastatic breast cancer following lumpectomy or mastectomy * Completed adjuvant chemotherapy (with or without radiotherapy) * Age ≥ 18 years * Able to understand and follow the study protocol * Willingness to attend facility-based exercise training. Exclusion Criteria: * Metastatic (Stage IV) breast cancer * Morbid obesity (BMI \> 40 kg/m²) * Uncontrolled hypertension (systolic blood pressure \> 180 mmHg and/or diastolic blood pressure \> 99 mmHg) * Presence of implantable medical devices (e.g., pacemakers, nerve stimulators) * Presence of metallic surgical implants (e.g., total hip or knee replacements) that interfere with assessment devices * Contraindications for resistance training (e.g., acute infectious disease, severe cardiac disease, severe respiratory insufficiency) * Concurrent malignant diseases * Current participation in intense systematic exercise training (defined as at least 1 hour, twice per week) * Previous participation in an exercise intervention clinical trial.

Study locations

Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Xindian Dist 231 Taiwan

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.