Recruiting

Global Collaborative Research on Establishing a Korean Cognitive Aging Cohort

ClinicalTrials.gov IDNCT07485387

PhaseNot Applicable

Enrollment180

SponsorKorea University

Age60 Years

SexALL

I'm interested View official listing

Conditions studied

Mild Cognitive Impairment (MCI), Dementia Alzheimer Type, Chronic Pain, Depression - Major Depressive Disorder

About this study

The goal of this observational study is to learn how daily emotional stress affects cognitive function and inflammation in community-dwelling older adults aged 60 and older in Seoul, Republic of Korea. The main questions it aims to answer are: Does daily psychological stress measured in real-time affect short-term and long-term cognitive function in older adults? Do pro-inflammatory cytokines (such as CRP, IL-6, IL-10, and TNF-α) mediate the relationship between emotional stress and cognitive decline? How do social support and social isolation influence cognitive function and inflammatory biomarkers over time? Participants will: Complete baseline surveys assessing depression, cognitive function, and personal characteristics Use a smartphone app to answer brief surveys about their emotions, cognitive performance, and social interactions 1-6 times daily for two weeks Wear a Galaxy Watch to track sleep quality, heart rate, and physical activity Provide blood samples for inflammatory biomarker analysis Return for follow-up assessments at 6 months and 1 year This study is part of an international collaboration to establish a Korean cohort comparable to the U.S. Einstein Aging Study, with the aim of developing culturally tailored dementia prevention strategies.

Primary outcomes

Incident MCI and Dementia Diagnosis (baseline, 6-month, 1-year, 5-year and 10-year follow-up)
SNSB-2 Composite Score (Baseline and 12 months)
Wechsler Memory Scale Score (Baseline, 6 months, and 12 months)
Block Design Subtest Score (Baseline, 6 months, and 12 months)
EMA Daily Cognitive Task Performance (Daily during 2-week EMA period at baseline, 6 months, and 12 months)
Plasma Phosphorylated Tau (p-tau) Level (Baseline, 6 months, and 12 months)
Pro-Inflammatory Cytokine Composite Score (Baseline, 6 months, and 12 months)
Plasma Amyloid Beta (Aβ) Level (Baseline, 6 months, and 12 months)

Eligibility information

Inclusion Criteria: * Adults aged 60 or older residing in the Republic of Korea * Samsung Galaxy smartphone users capable of using smartphone applications * Sufficient cognitive ability to understand and follow research instructions (MMSE score of 21 or above) * For individuals who do not meet the cognitive criteria, those who understand the study procedures and provide informed consent along with their legal guardian Exclusion Criteria: * Diagnosis of dementia at baseline * Severe visual or hearing impairments that prevent participation in psychological assessments * Illiteracy that prevents participation in cognitive testing * Less than 80% compliance with the 2-day preliminary EMA protocol (one additional attempt allowed after re-training) * Current alcohol or substance abuse * Inability to ambulate or psychiatric conditions that prevent survey participation * Currently undergoing cancer treatment or received chemotherapy within the past 6 months

Study locations

Korea University, Seoul, Select One... 02841 South Korea

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.