Recruiting

Assessment of Pancreatic Dysfunction in Patients With Type 2 Diabetes

ClinicalTrials.gov IDNCT07512934

PhaseNot Applicable

Enrollment310

SponsorWest Kazakhstan Marat Ospanov Medical University

Age18 Years

SexALL

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Conditions studied

Pancreatogenic Diabetes Mellitus, Type 2 Diabetes Mellitus (T2DM), Exocrine Pancreatic Insufficiency (EPI)

About this study

The goal of this observational study is to better understand how the pancreas works in adults with type 2 diabetes. The study focuses on both hormone production (endocrine function) and digestive function (exocrine function) of the pancreas. The main questions it aims to answer are: * Can problems with the pancreas help identify a different type of diabetes called pancreatogenic diabetes? * How are blood markers and pancreas structure related to pancreatic function? Participants will: * Have blood tests to measure glucose, insulin, and other markers * Provide a stool sample to assess digestive function * Undergo an ultrasound examination of the pancreas * Answer questions about digestive symptoms The study will take place during a single visit in outpatient clinics.

Primary outcomes

Prevalence of pancreatogenic diabetes (At single study visit (baseline))

Eligibility information

Inclusion Criteria: * • adult patients of Kazakh nationality aged 18 to 74 years * diagnosis of T2DM established according to ADA criteria and documented in medical records * disease duration ≤5 years * absence of ketoacidosis episodes within the last 6 months Exclusion Criteria: * positive anti-glutamic acid decarboxylase antibodies (anti-GAD65); * acute or chronic infections affecting metabolic status within the previous 4 weeks; * any history of malignant neoplasms; * pregnancy or lactation; * previously diagnosed type 1 diabetes mellitus or other specific types of diabetes; * severe decompensated chronic diseases; * conditions associated with systemic fibrosis (e.g., liver cirrhosis or autoimmune diseases); * refusal to participate.

Study locations

Outpatient clinics of Aktobe region, West Kazakhstan Marat Ospanov Medical University, Aktobe, Aktobe 030019 Kazakhstan

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.