Vascular Complications After Kidney Transplantation
* To determine the incidence of arterial inflow problems and venous outflow problems as causes of impaired renal function and/or treatment-resistant hypertension after kidney transplantation, when all kidney-transplant recipients in Denmark are evaluated according to uniform, well-defined clinical criteria. * To investigate the efficacy and safety of catheter-based balloon treatment (percutaneous transluminal angioplasty, PTA) for these vascular complications, of which transplant renal artery stenosis is by far…
Conditions studied
Kidney Transplant Recipient, Kidney Transplant; Complications, Transplant Renal Artery Stenosis, Renovascular Disease, Renal Transplant Graft Failure, Renovascular Hypertension, Heart Failure
About this study
* To determine the incidence of arterial inflow problems and venous outflow problems as causes of impaired renal function and/or treatment-resistant hypertension after kidney transplantation, when all kidney-transplant recipients in Denmark are evaluated according to uniform, well-defined clinical criteria. * To investigate the efficacy and safety of catheter-based balloon treatment (percutaneous transluminal angioplasty, PTA) for these vascular complications, of which transplant renal artery stenosis is by far the most common. * To assess whether novel imaging and functional diagnostic methods can predict treatment response.
Interventions
- Diagnostic Test: Catheter-based angiography — Catheter-based angiography performed in accordance with the study protocol.
- Diagnostic Test: Measurement of translesional pressure gradients — Measurement of translesional pressure gradients performed in accordance with the study protocol.
- Diagnostic Test: Intravascular ultrasound (IVUS) — Intravascular ultrasound (IVUS) performed in accordance with the study protocol.
- Procedure: Percutaneous transluminal angioplasty (PTA) — Percutaneous transluminal angioplasty (PTA) is performed in accordance with the study protocol. As a general principle, bare-metal stents (BMS) are used. Drug-eluting stents (DES) may be considered when the arterial lumen diameter is \< 4-5 mm. In stenoses where stent placement carries a risk of side-branch occlusion, PTA is performed without stent implantation and most often with a drug-coated balloon (DCB).
Primary outcomes
- Change in measured glomerular filtration rate (mGFR). (Baseline and 3 months post-PTA.)
Eligibility information
Study locations
- Aarhus University Hospital, Aarhus, 8200 Denmark
- Rigshospitalet, Copenhagen, 2100 Denmark
- Odense University Hospital, Odense, 5000 Denmark
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.