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Role of Endothelial Progenitor Cells Dysregulation and Inflammation in the Pathophysiology of Cardiovascular Complications of Type 2 Diabetes

This study aims to isolate endothelial progenitor cells (EPCs) from participants with type 2 diabetes (T2D) and cardiovascular complications and to comprehensively characterize EPC dysfunction. Specifically, the study will evaluate maladaptive angiocrine signaling, calcium signaling pathways, and the role of inflammation in EPC function and the progression of atherosclerosis during T2D development. A sub-study will assess EPC functionality by examining endothelial nitric oxide synthase (eNOS) expression and…

ClinicalTrials.gov IDNCT07556497

PhaseNot Applicable

Enrollment90

SponsorWeill Cornell Medical College in Qatar

Age18 Years

SexALL

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Conditions studied

Diabete Type 2, Cardio Vascular Disease

About this study

Primary outcomes

Characterization of EPCs dysregulation in Type 2 diabetes (Following the EPC isolation (15 - 20 days).)
Functional Analysis of inflammatory responses in Endothelial Progenitor Cells in type 2 Diabetes with cardiovascular complications (Following the EPC isolation (15 - 20 days))

Eligibility information

Inclusion Criteria: * T2D * Males and females * Older than 18 years of age * Willingness to participate in the study and provide written consent form * Consent to having peripheral blood withdrawals and urine collection for the study requirement. Exclusion Criteria: * Unable to meet the inclusion criteria * Type I diabetes, MODY diabetes or other form of diabetes * Active infection, inflammation, cancer or acute illness of any kind (other than a cardiovascular complication of diabetes if applicable in the group they are assigned to). * Chronic inflammation (eg. auto-immune diseases) or infections (eg. HIV, chronic hepatitis). * Evidence of malignancy within the past 5 years

Study locations

Hamad Medical Corporation, Doha, Qatar

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.