Recruiting
18F-T2 PET/CT Imaging for CAIX Positive Solid Tumors
The goal of this clinical trial is to evaluate the diagnostic value of CAIX protein specific probe 18F-T2 in PET/CT imaging in participants with solid tumors. It will also assess the safety, tolerability and radiation dosimetry of 18F-T2.
ClinicalTrials.gov IDNCT07557225
PhaseNA
Enrollment200
SponsorPeking University First Hospital
Age18 Years
SexALL
Conditions studied
Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC), Colorectal Cancer, Cervical Cancer, Ovarian Cancer, Head and Neck Cancer, Hepatocellular Carcinoma (HCC), Cholangiocarcinoma, Non Small Cell Lung Cancer, Small Cell Lung Cancer, Breast Cancer, Pancreatic Cancer, Endometrial Cancer, Von Hippel Lindau Disease
About this study
The goal of this clinical trial is to evaluate the diagnostic value of CAIX protein specific probe 18F-T2 in PET/CT imaging in participants with solid tumors. It will also assess the safety, tolerability and radiation dosimetry of 18F-T2.
Interventions
- Diagnostic Test: 18F-T2 PET/CT — 18F-T2 is injected intravenously with a dose of 0.05-0.10 mCi/kg. The CT and PET imaging session will begin approximately 60 minutes after 18F-T2 administration.
Primary outcomes
- The Diagnostic Sensitivity and Specificity of 18F-T2 PET/CT in the Evaluation of CAIX Positive Solid Tumors (From study completion to 1 month after completion)
- Incidence of Adverse Events [Safety and Tolerability] (24 hours after the injection of 18F-T2)
Eligibility information
Inclusion Criteria:
All participants must meet the following criteria:
1. Written and voluntarily given Informed Consent.
2. Male or female ≥18 years of age at time of consent.
3. Have the capacity to understand the study and be willing and able to comply with all protocol requirements.
4. Participants with histologically confirmed or suspected tumors of the following types, but not limited to:
Clear Cell Renal Cell Cancer; Urothelial Carcinoma; Colorectal Cancer; Cervical Cancer; Ovarian Cancer; Head and Neck Cancer; Hepatocellular Carcinoma; Cholangiocarcinoma; Non Small Cell Lung Cancer; Small Cell Lung Cancer; Breast Cancer; Pancreatic Cancer; Endometrial Cancer; Von Hippel Lindau Disease.
Exclusion Criteria:
Participants will be excluded from participation in the study if one or more of the following criteria are met:
1. Have any serious non-malignant disease (e.g., psychiatric, infectious, autoimmune or metabolic) that may interfere with the objectives of the study or with the safety or compliance of the participant, as judged by the Investigator.
2. Have a mental impairment that may compromise the ability to give Informed Consent and comply with the requirements of the study.
3. Be a female who is pregnant or breastfeeding.
Study locations
- Peking University First Hospital, Beijing, Beijing Municipality 100034 China
Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.