Recruiting
EFFECTS OF PROPOLIS AND ROYAL JELLY SUPPLEMENTATION ON INFLAMMATORY AND OXIDATIVE STRESS MARKERS IN PATIENTS WITH SYSTEMIC ARTERIAL HYPERTENSION
The study aims to evaluate the effect of the royal jelly and propolis on inflammation and oxidative stress in participants with systemic arterial hypertension. A longitudinal double-blind randomized clinical trial will be carried out, involving hypertensive participants for two months.
ClinicalTrials.gov IDNCT07596966
PhaseNA
Enrollment48
SponsorUniversidade Federal Fluminense
Age18 Years
SexALL
Conditions studied
Systemic Arterial Hypertension, Inflammation
About this study
The study aims to evaluate the effect of the royal jelly and propolis on inflammation and oxidative stress in participants with systemic arterial hypertension. A longitudinal double-blind randomized clinical trial will be carried out, involving hypertensive participants for two months.
Interventions
- Dietary Supplement: Placebo — The placebo group will receive 4 capsules per day (containing microcrystalline cellulose and magnesium stearate in colored gelatin capsules capable of masking the appearance of the internal content), at the same time for 2 months.
- Dietary Supplement: Royal Jelly + Propolis Group — Participants will receive 4 capsules per day, providing the dosage of 300mg of royal jelly + 500mg propolis for 2 months (8 weeks).
Primary outcomes
- Change of inflammatory citokynes (Baseline and 2 months)
Eligibility information
Inclusion Criteria:
* Diagnosis of stage 1 and 2 hypertension
* Regular treatment for more than 6 months
* There have been no changes in medication doses over the last three months.
Exclusion Criteria:
* Autoimmune and infectious diseases, diabetes
* Chronic kidney disease, liver disease, cancer and AIDS
* Pregnant women
* Use of catabolic drugs or antibiotics
* Use of antioxidant vitamin supplements, prebiotics, probiotics, symbiotic
* Habitual intake of royal jelly and propolis
Study locations
- Denise Mafra, Niterói, Rio de Janeiro 24220-900 Brazil
Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.