Uppsala Self-Screening of Cardiovascular Health

Conditions studied

Cardiovascular Diseases, Hypertension, Dyslipidemias, Diabetes Mellitus, Atrial Fibrillation, Chronic Kidney Disease

About this study

U-SCREEN is a randomized controlled trial evaluating whether systematic home-based multimodal screening for cardiovascular risk conditions, offered to residents in Region Uppsala turning 50, 55, 60, 65, 70 or 75 years of age, can identify clinically actionable cardiovascular risk factors more effectively than usual care. Participants randomized to the screening arm receive a home blood pressure measurement device, a dried blood spot sampling kit (for ApoB, HbA1c and creatinine), and a digital questionnaire. The control arm receives usual care. Recruitment runs 2024-2027 with a target identification of 10,000 cardiovascular risk conditions.

Interventions

• Behavioral: Home-based multimodal cardiovascular screening — Self-administered home-based screening program: 7-day home BP, DBS biomarker self-sampling, digital questionnaire; structured digital return of results; threshold-based initiation of guideline-recommended pharmacotherapy and referral to clinical care.

Primary outcomes

• Rate of total major adverse cardiovascular events over 10 years (Within 10 years after randomization)
• Number of initiated guideline-recommended pharmacotherapies for cardiovascular risk factors within 12 months (Within 12 months after randomization)

Eligibility information

Study locations

• Uppsala University Hospital, Uppsala, 751 85 Sweden