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DASH-Obesity: Explainable AI for Family-Centric Personalized Weight Control in Adolescents and Young Adults With Obesity and Chronic Conditions

This prospective single-arm feasibility study evaluates the Adhera Caring Digital Program for Obesity (ACDP-O), a family-centered digital health intervention designed to support adolescents and young adults with overweight/obesity and chronic conditions, including type 1 diabetes (T1D) and asthma. The intervention combines personalized educational content, wearable-device monitoring, psychometric assessments, and explainable artificial intelligence (AI) to improve mental well-being, quality of life, and adherence…

ClinicalTrials.gov IDNCT07638345

PhaseNA

Enrollment280

SponsorAdhera Health, Inc.

Age18 Years

SexALL

I'm interested View official listing

Conditions studied

Type 1 Diabetes, T1D, Obesity & Overweight, Obesity Type 2 Diabetes Mellitus, Asthma Acute, Asthma (Diagnosis)

About this study

Interventions

Behavioral: Adhera Caring Digital Program-Obesity (ACDP-O) — The Adhera Caring Digital Program-Obesity (ACDP-O) is a mobile-based digital health intervention that provides personalized educational content, cognitive behavioral approach-based support, psychometric monitoring, wearable-device integration, remote monitoring, and explainable artificial intelligence tools. The intervention is designed to support weight management, healthy lifestyle behaviors, mental well-being, quality of life, and family engagement in adolescents and young adults with obesity and chronic conditions

Primary outcomes

Feasibility of the ACDP-O Intervention (Baseline to Day 90)
Acceptability of the ACDP-O Intervention (Day 90)
Change in Mental Well-being (DASS-21) (Baseline and Day 90)
Change in Family Well-being (Baseline and Day 90)
Change in Quality of Life (Distress) (Baseline and Day 90)
Change Quality of Life (KIDSCREEN-10) (Baseline and Day 90)

Eligibility information

Inclusion Criteria: * Adult caregiver (aged 18 years or older) of an adolescent or young adult aged 12 to 21 years diagnosed with Type 1 Diabetes (T1D) or asthma. * The caregiver is actively involved in the management of the adolescent's or young adult's condition. * The adolescent or young adult must meet one of the following criteria: * T1D and normal weight (BMI between the 10th and 85th percentile), or * T1D and overweight/obesity (BMI ≥85th percentile), or * Asthma and overweight/obesity (BMI ≥85th percentile). * Willingness to participate in the Adhera Caring Digital Program-Obesity (ACDP-O). * Access to a smartphone or internet-enabled device compatible with the study application. * Willingness to provide self-reported information regarding the adolescent's or young adult's health status, including disease-related and anthropometric measures. * For caregivers of participants with T1D, willingness to share continuous glucose monitoring (CGM) information. Exclusion Criteria: * Severe psychiatric or cognitive conditions that would interfere with participation in the digital intervention. * Current participation in another obesity- or chronic disease-related digital health intervention study. * Inability or unwillingness to comply with study procedures. * Refusal or inability to provide informed consent.

Study locations

Adhera Health (Virtual Participation), Seville, Spain

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.