Risk Factor Assessment for Acute Pulmonary Hypertension Crisis
The goal of this observational study is to learn about pulmonary hypertension crisis (PHC) - a severe, and often fatal complication - in patients with pulmonary hypertension (PH). The main questions this study aims to answer are: What are the clinical and hemodynamic features of PHC, and what underlying pathophysiological mechanisms cause it to develop? Can these features be used to diagnostic PHC, predict who is at risk of developing it or dying from it, and develop targeted prevention and treatment of PHC? A…
Conditions studied
Pulmonary Hypertension, Pulmonary Hypertension Crisis
About this study
The goal of this observational study is to learn about pulmonary hypertension crisis (PHC) - a severe, and often fatal complication - in patients with pulmonary hypertension (PH). The main questions this study aims to answer are: What are the clinical and hemodynamic features of PHC, and what underlying pathophysiological mechanisms cause it to develop? Can these features be used to diagnostic PHC, predict who is at risk of developing it or dying from it, and develop targeted prevention and treatment of PHC? A multi-center registry platform and biobank will be established to enroll and follow up patients with PH. Clinical data, hemodynamic measurements, and biological specimen will be collected. Risk prediction and early warning tools of PHC will be developed.
Primary outcomes
- Pulmonary hypertension crisis (From enrollment to 3 years after enrollment)
- 28 day mortality attributed to pulmonary hypertension crisis (From hospitalization to 28 days)
Eligibility information
Study locations
- Guangdong Province People's Hospital, Guangzhou, Guangdong China
- Yan'an Affiliated Hospital of Kunming Medical University, Kunming, Yunnan China
- Peking Union Medical College Hospital, Beijing, 100730 China
- Shanghai Pulmonary Hospital, Shanghai, China
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.