A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus
The purpose of this study is to evaluate the efficacy, safety, and tolerability of elecoglipron compared with oral semaglutide in adults with T2DM and increased cardiovascular risk that is inadequately managed alone or on stable treatment with other background glucose-lowering medication(s).
Conditions studied
Type 2 Diabetes Mellitus
About this study
The purpose of this study is to evaluate the efficacy, safety, and tolerability of elecoglipron compared with oral semaglutide in adults with T2DM and increased cardiovascular risk that is inadequately managed alone or on stable treatment with other background glucose-lowering medication(s).
Interventions
- Drug: Elecoglipron — Elecoglipron is administered orally once daily.
- Drug: Semaglutide — Semaglutide is administered orally once daily.
Primary outcomes
- Change from baseline in Hemoglobin A1c (HbA1c) (Baseline to Week 52)
Eligibility information
Study locations
- Research Site, Birmingham, Alabama 35205 United States
- Research Site, Mesa, Arizona 85213 United States
- Research Site, Phoenix, Arizona 85016 United States
- Research Site, Tempe, Arizona 85281 United States
- Research Site, Covina, California 91723 United States
- Research Site, Encinitas, California 92024 United States
- Research Site, Garden Grove, California 92844 United States
- Research Site, Loma Linda, California 92354 United States
- Research Site, Long Beach, California 90807 United States
- Research Site, Pomona, California 91768 United States
Showing 10 of 209 reported sites. See the official listing for all locations.
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-09-27.