A Research Study Comparing How Well Different Doses of the Medicine UBT251 Lower Blood Sugar in People With Type 2 Diabetes
The study is testing UBT251 in participants with type 2 diabetes. The purpose of this clinical study is to find out if UBT251 is effective and safe for treating participants with type 2 diabetes. Participants will either get UBT251, UBT251 placebo, semaglutide, or semaglutide placebo. Which treatment participants get is decided by chance. UBT251 is the treatment being tested and is not yet available for doctors to prescribe, while semaglutide is a medicine used to treat type 2 diabetes that doctors can already…
Conditions studied
Diabetes Mellitus, Type 2
About this study
The study is testing UBT251 in participants with type 2 diabetes. The purpose of this clinical study is to find out if UBT251 is effective and safe for treating participants with type 2 diabetes. Participants will either get UBT251, UBT251 placebo, semaglutide, or semaglutide placebo. Which treatment participants get is decided by chance. UBT251 is the treatment being tested and is not yet available for doctors to prescribe, while semaglutide is a medicine used to treat type 2 diabetes that doctors can already prescribe.
Interventions
- Drug: UBT251 — UBT251 will be administered subcutaneously once-weekly.
- Drug: UBT251 Placebo — UBT251 placebo will be administered subcutaneously once-weekly.
- Drug: Semaglutide — Semaglutide will be administered subcutaneously once-weekly.
- Drug: Semaglutide Placebo — Semaglutide placebo will be administered subcutaneously once-weekly.
Primary outcomes
- UBT251: Change in glycated haemoglobin (HbA1c) (From baseline (week 0) to 12 weeks on a given maintenance dose (week 16, 28 and 40))
Eligibility information
Study locations
- Flourish Research, Birmingham, Alabama 35205 United States
- Ark Clinical Research, Fountain Valley, California 92708 United States
- Ark Clinical Research, Long Beach, California 90815 United States
- Los Angeles Institute for Metabolic Research, Los Angeles, California 90015 United States
- Catalina Research Institute, LLC, Montclair, California 91763 United States
- Encore Medical Research LLC, Hollywood, Florida 33024 United States
- South Broward Research LLC, Miramar, Florida 33027 United States
- Encore Medical Research of Weston, Weston, Florida 33331 United States
- Midwest Inst For Clin Res, Indianapolis, Indiana 46260 United States
- Cotton O'Neil Diabetes & Endocrinology, Topeka, Kansas 66606 United States
Showing 10 of 70 reported sites. See the official listing for all locations.
Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-11-12.