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Aerobic Exercise as an Adjunct Therapy for Depression

The goal of this study is to compare the reduction in the severity of depression after a duration of 06 weeks between patients receiving conventional therapy (antidepressant; Sertraline) only and those receiving both conventional therapy and a structured aerobic exercise (cycling, brisk walking).

ClinicalTrials.gov IDNCT07819448

PhaseNA

Enrollment66

SponsorManahil Gill

Age18 Years – 55 Years

SexALL

I'm interested View official listing

Conditions studied

Depressive Disorder

About this study

Interventions

Behavioral: Structured Aerobic exercise — Participants will receive structured, supervised aerobic exercise ( cycling, brisk walking), in addition to conventional treatment consisting of 03 sessions per week, 35 minutes each for 06 weeks.

Primary outcomes

Change in Beck Depression Inventory (BDI) score (Baseline to 06 weeks)

Eligibility information

Inclusion Criteria: i. All new patients diagnosed with moderate and severe depression using BDI scale according to ICD-11 criteria between the ages of 18-55 years. ii. Both genders will be included. Exclusion Criteria: i. Patients with severe physical disabilities such as Spinal cord injuries, severe osteoporosis or medical conditions that prevent exercise such as ischemic changes in ECG pre-exercise. ii. Pregnant females. iii. Individuals already engaging in physical activities like athletes.

Study locations

CMH Bahawalpur, Chak Four Hundred Fifty-four, Punjab Province 63100 Pakistan

Before you participate: Varda Clinical is an independent discovery tool, not the study sponsor or a medical provider. Eligibility can only be determined by the official study team. Discuss potential risks and benefits with a qualified healthcare professional.

Source: ClinicalTrials.gov. Record last refreshed by Varda Clinical: 2026-10-14.